Breast disease: dynamic spiral MR imaging.

Daniel, Bruce L.; Yen, Yi‐Fen; Glover, Gary H.; Ikeda, Debra M.; Birdwell, Robyn L.; Sawyer-Glover, Anne M.; Black, J W; Plevritis, Sylvia K.; Jeffrey, Stefanie S.; Herfkens, Robert J.

doi:10.1148/radiology.209.2.9807580

Cited by 179 publications

(126 citation statements)

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“…1B) is that often reported as characteristic of such tumors: much faster and greater uptake (followed by washout) compared with a benign lesion such as that of Fig. 1D (13,(20)(21)(22)(23). The mean arterial input function (AIF), determined from axillary artery 1 H 2 O signal time courses in 3 patients, shows the plasma CR concentration, [CR p ], peaking near 5 mM at Ϸ0.75 min (Fig.…”

Section: Resultsmentioning

confidence: 83%

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Huang

Morris

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

147

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The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue 1 H2O relaxation and thus MR image intensity. For longitudinal relaxation [R1 ϵ (T1) ؊1 ], the CR must have transient molecular interactions with water. Because the CR and water molecules are never uniformly distributed in the histological-scale tissue compartments, the kinetics of equilibrium water compartmental interchange are competitive. In particular, the condition of the equilibrium transcytolemmal water exchange NMR system sorties through different domains as the interstitial CR concentration, [CRo], waxes and wanes. Before CR, the system is in the fast-exchange-limit (FXL). Very soon after CRo arrival, it enters the fast-exchange-regime (FXR). Near maximal [CRo], the system could enter even the slowexchange-regime (SXR). These conditions are defined herein, and a comprehensive description of how they affect quantitative pharmacokinetic analyses is presented. Data are analyzed from a population of 22 patients initially screened suspicious for breast cancer. After participating in our study, the subjects underwent biopsy/pathology procedures and only 7 (32%) were found to have malignancies. The transient departure from FXL to FXR (and apparently not SXR) is significant in only the malignant tumors, presumably because of angiogenic capillary leakiness. Thus, if accepted, this analysis would have prevented the 68% of the biopsies that proved benign.water exchange ͉ screening ͉ shutter speed

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Section: Resultsmentioning

confidence: 83%

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Huang

Morris

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

147

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“…In general, focally enhancing lesions that measured Ն 5 mm prompted follow-up MRI, initially at 6 months, to ensure stability. Dominant lesions that measured Ն 5 mm with either suspicious morphologic features (e.g., rim enhancement, spiculation, linear-branching enhancement 34 ) or suspicious dynamic enhancement features (e.g., rapid, intense, initial enhancement followed by an abrupt transition to a stable plateau signal intensity or an abrupt transition to a decreasing wash-out signal intensity 35 ) were biopsied. The radiologist (B.L.D.)…”

Section: Mr Protocolmentioning

confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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“…Breast cancer screening has been a major thrust for DCE-MRI (19)(20)(21)(22), particularly because of the angiogenic nature of the tumors (20,23). At least because of its greater sensitivity compared with other modalities, the recent advocacy for increased MRI breast screening favors DCE-MRI (2, 3).…”

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confidence: 99%

The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo

Huang

Morris

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

129

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The pharmacokinetic analysis of dynamic-contrast-enhanced (DCE) MRI data yields K trans and kep, two parameters independently measuring the capillary wall contrast reagent transfer rate. The almost universally used standard model (SM) embeds the implicit assumption that equilibrium transcytolemmal water exchange is effectively infinitely fast. In analyses of routine DCE-MRI data from 22 patients with suspicious breast lesions initially ruled positive by institutional screening protocols, the SM K trans values for benign and malignant lesions exhibit considerable overlap. A form of the shutter-speed model (SSM), which allows for finite exchange kinetics, agrees with the SM K trans value for each of the 15 benign lesions. However, it reveals that the SM underestimates K trans for each of the seven malignant tumors in this population. The fact that this phenomenon is unique to malignant tumors allows their complete discrimination from the benign lesions, as validated by comparison with gold-standard pathology analyses of subsequent biopsy tissue samples. Likewise, the SM overestimates k ep, particularly for the benign tumors. Thus, incorporation of the SSM into the screening protocols would have precluded all 68% of the biopsy/pathology procedures that yielded benign findings. The SM/SSM difference is well understood from molecular first principles.cancer ͉ water exchange ͉ MRI ͉ screening ͉ DCE S creening for breast cancer represents one of modern medicine's success stories. However, the continued large fraction of false positives in current diagnostic protocols (1) often leads to biopsy/ pathology procedures that append considerable pain, anxiety, healthcare cost, and possibly increased malignancy risk, but that are potentially avoidable. To address this problem, there have been recent calls for the increased use of magnetic resonance imaging (MRI) in breast screening (2, 3).Early in the development of medical MRI, it was realized that hydrophilic paramagnetic molecules could enhance image contrast, and that the shape of the water proton ( 1 H 2 O) signal intensity time course after a bolus injection of such a contrast reagent (CR) contained considerable patho-physiological information, promising even possible quantitative vascular phenotyping.Major efforts have been mounted for the pharmacokinetic analyses of such time-course data (4). It was natural that mathematical models for these were taken from the field of nuclear medicine, where such algorithms have matured. However, these were developed for tracer pharmacokinetics, with the intrinsic feature of direct radiotracer detection. Although the MRI CR plays the tracer role, the signal molecule remains water: the CR is detected only indirectly, via its effect on the nature of tissue 1 H 2 O relaxation. Affecting the recovery of longitudinal 1 H 2 O magnetization (i.e., in the magnetic field direction) requires (transient) water CR molecular interaction, as depicted in Fig. 1. The three major loci for tissue water, the cytoplasmae, the interstitium, and the bloo...

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Breast disease: dynamic spiral MR imaging.

Abstract: Dynamic spiral breast MR imaging proved an excellent method with which to collect contrast enhancement data rapidly enough that accurate comparisons can be made between many analytic methods.

Cited by 179 publications

References 0 publications

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo

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