Breast Diseases in Males

Vetto, John T.

doi:10.1007/978-3-540-69743-5_25

Cited by 4 publications

(5 citation statements)

References 239 publications

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“…On failure, second-line hormonal may include orchiectomy or luteinizing hormone-releasing hormone agonists with or without antiandrogens [26]. Chemotherapy is indicated in receptor negative or non-responders [20]. In the present series, patients on tamoxifen failure were treated with chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

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Male Breast Cancer: A Clinicopathologic Study of 42 Patients in Eastern India

Shah

Bhattacharyya

Gupta

et al. 2012

Indian J Surg Oncol

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Retrospective review of presentation, treatment and outcome of male breast cancer in a tertiary cancer centre in eastern India. Data of 42 male breast cancer (MBC) patients, who presented between April, 2001 and March, 2008 were collected from institute records with respect to epidemiological characteristics, clinical and pathological parameters, treatment pattern and outcome. This series includes 42 patients with mean age of 56 years (range 31-78 years). MBC represented 1.1 % of all breast cancer. History of lump in the breast with duration ranging from 1 month to 4 years was the most common clinical presentation (80.95 %). Histopathology found infiltrating ductal carcinoma in 35 (83.33 %), followed by papillary carcinoma in 3 (7.14 %), undifferentiated carcinoma in 2 (4.76 %), mucinous carcinoma in 1 (2.38 %) and myxofibrosarcoma in 1 (2.38 %) patient. Hormone receptor (HR) study was performed on 29 patients. Twenty six (89.7 %) patients were hormone receptor positive in that 8 (27.6 %) were ER positive and 18 (62.1 %) were ER and PR positive. 3 (10.3 %) were hormone receptor negative.Axillary lymph node dissection was performed on 30 patients. Of those, 60 % were found to be positive (pN+) and 40 % were negative (pN-). Of the patients with invasive carcinoma 2.86 % were pathologic stage I, 37.14 % stage II, 42.86 % stage III and 17.14 % stage IV. Of the 35 treated patients, total 30 (85.71 %) patients underwent surgery. The surgery consisted of a modified radical mastectomy (MRM) 24 (80 %), radical mastectomy according to Halsted (RM) 6 (20 %). Adjuvant therapy i.e. Chemotherapy and Radiotherapy was administered to the patient based upon their stage. The standard treatment for all HR positive patients was administration of tamoxifen. Based upon the follow-up information (ranging from 17 month to 136 months), 4 (14.28 %) patients developed local recurrence over 4 to 26 months (mean17.5 months) and 5 patients developed distant metastasis over 24 to132 months (mean 78 months). Disease specific survival varied from 4 months to 132 months, with a mean of 56.75 months. Thirteen out of 28 evaluable patients (46.43 %) were disease free at 5 years. Male Breast cancer is a rare disease often ignored in the community, because of which it is seeks medical attention at advanced stage. Majority of MBC are found to be HR positive, hence hormonal therapy should to be strongly considered and multicentric prospective studies are needed to improve outcome.

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Section: Resultsmentioning

confidence: 99%

“…Of the 28 evaluable patients treated with surgery with curative intent, 4 (14.28 %) patients developed local recurrence. The postoperative locoregional recurrence rate without radiotherapy has been reported to vary from 4 to 31 % [20].…”

Section: Resultsmentioning

confidence: 99%

Male Breast Cancer: A Clinicopathologic Study of 42 Patients in Eastern India

Shah

Bhattacharyya

Gupta

et al. 2012

Indian J Surg Oncol

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“…Unlike female breast cancer, incidence rates are higher in African American men than Caucasian men [2,12]. Due to lack of routine breast cancer screening and possibly lack of public awareness, men often present with higher stage disease, larger tumors and more frequent lymph node involvement [11,13].…”

Section: Discussionmentioning

confidence: 99%

“…The most common histologic subtype is invasive ductal carcinoma, representing 90% [11,13]. Lobular carcinoma accounts for 1.5% of cases.…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Male Breast Cancer and a Review of the Literature

Z¹

2019

CRIJ

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The incidence of male breast cancer is uncommon, occurring in <1% of the population. Synchronous breast cancer in men is exceedingly rare and less common than metachronous bilateral breast cancer. One study spanning 20 years and involving 2524 male breast cancer patients estimated that 2.1% were synchronous while 2.3% were metachronus. We present a case of synchronous breast cancer in a 70 year-old male with a family history of breast cancer. In this case report we review the epidemiology, radiologic workup, imaging findings and management decisions for male breast cancer.

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