Breast metaplastic carcinoma with unusual small cell component

AbdullGaffar, Badr; Ghazi, E. El; Mohamed, Eliza; Hamza, Dina

doi:10.3233/bd-130346

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…5 Metaplastic carcinoma with neuroectodermal differentiation should be considered, so extensive sampling and immunohistochemical investigation are compulsory to do. 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma: An Uncommon Breast Tumor

Meddeb

Rhim

Kouira

et al. 2014

Clinics and Practice

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Ewing’s sarcoma/primitive neuroectodermal tumors (EWS/PNET) are rare malignant and aggressive tumors, usually seen in the trunk and lower limbs of children and young adults. They are uncommon in the breast. We report a case of a 43-year-old woman who developed a painless breast mass. An initial core needle biopsy concluded to a fibrocystic dystrophy contrasting with a rapidly growing mass; thus a large lumpectomy was done. Diagnosis of primary PNET of the breast was established, based on both histopathological examination and immunohistochemical findings. Surgical margins were positive, therefore, left modified radical mastectomy with axillary lymph nodes dissection was performed. The patient was given 6 cycles of adjuvant chemotherapy containing cyclophosphamide, adriamycin and vincristine. Twenty months later, she is in life without recurrence or metastasis. EWS/PNET may impose a diagnostic challenge. Indeed, mammography and ultrasonography features are non specific. The histopathological pattern is variable depending on the degree of neuroectodermal differentiation. Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

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“…5 Metaplastic carcinoma with neuroectodermal differentiation should be considered, so extensive sampling and immunohistochemical investigation are compulsory to do. 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

Ewing’s Sarcoma: An Uncommon Breast Tumor

Meddeb

Rhim

Kouira

et al. 2014

Clinics and Practice

View full text Add to dashboard Cite

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“…However, the most popular methods, including X-ray mammography, ultrasonic imaging, and breast magnetic resonance imaging, essentially provide morphological and structural information (Gautherie, 1980;Anderson et al, 2005;Aupperlee et al, 2005;AbdullGaffar et al, 2012). However, many types of aggressive tumors containing fewer than 500,000 cells (<2 mm in diameter) are likely to pass undetected through most of these scans (Gescheit et al, 2010;Absalan et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of internal heat source analysis for breast cancer identification

et al. 2015

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ABSTRACT. Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis was used to calculate the internal heat source (i.e., tumor) thermal power for each participant. The applicability and effectiveness of our approach were estimated using the chi-square test, kappa statistics (k), and odds ratios (OR). Breast density and tumor size were considered during this estimation. A thermal power q = 0.2 w was determined as the optimal separation threshold between breast cancer and benign disease. Moreover, good agreement (k = 0.837) with the gold-standard assessment (breast biopsy) was confirmed in 93.2% of the patients (N = 884/948), and the sensitivity and specificity were 94.2 and 92.9%, respectively. The results also found no significant differences in methodological accuracy between the fatty and dense breasts (OR = 1.194, P = 0.524). Furthermore, after dividing the cohort into three groups according to tumor size (T1: <2 cm; T2: 2 to 5 cm; T3: >5 cm), the tumor size had no effect on the proposed method (ORs = 1, P = 0.724). Internal heat source analysis can feasibly 1451Internal heat source analysis of breast cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 1450-1460 (2015) and efficiently distinguish between breast cancer and benign disease.

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A Simple and Efficient Method for Breast Cancer Diagnosis Based on Infrared Thermal Imaging

Han

Shi

Liang

et al. 2014

Cell Biochem Biophys

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This study aims to evaluate the feasibility and efficacy of quantitative diagnosis through thermal analysis of abnormal metabolism. In this paper, an analytical-based steady-state solution for the thermal inverse problem was developed, considering an equivalent point heat source embedded in the tissue. Based on this solution, we developed a simple and efficient algorithm that generates solutions for the nonlinear heat conduction model. Using the nonlinear fitting analysis, a regular distribution can be derived from the raw thermal patterns of the skin surface above the tumor, and the power and depth of the equivalent heat source can be derived to investigate whether the tumor is malignant or benign. The thermal power Q of internal heat source was estimated to predict the satisfactory approaches to distinguish between benign and malignant tumors. The results of four clinical cases (female patients with malignant tumor and benign tumor) show that the estimated values of the power of the heat sources in malignant cases (fatty: Q = 0.34851 W; dense: Q = 0.46933 W) are both far greater than the ones in benign (fatty: Q = 0.04721 W; dense: Q = 0.07717 W), irregardless of the breast density. The correlation coefficients (R (2)) of the nonlinear curve fittings are all above 0.98. The new thermal method proposed in this study would help to improve the preciseness of diagnosis on breast masses (malignant or benign).

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Breast metaplastic carcinoma with unusual small cell component

Cited by 5 publications

References 10 publications

Ewing’s Sarcoma: An Uncommon Breast Tumor

Ewing’s Sarcoma: An Uncommon Breast Tumor

Clinical applications of internal heat source analysis for breast cancer identification

A Simple and Efficient Method for Breast Cancer Diagnosis Based on Infrared Thermal Imaging

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