Breast phantom for mammary tissue characterization by near infrared spectroscopy

Miranda, David A.; Cristiano, K. L.; Gutiérrez, Jesús Villa

doi:10.1088/1742-6596/466/1/012018

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…Tissue phantoms are used widely for system characterization and calibration of optical imaging and spectroscopy instruments, including multimodality systems incorporating ultrasound or nuclear modalities 1,2,3,4 . Phantoms provide a controlled optical environment for system characterization and quality control of multiple biological imaging techniques.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Durkee

Nash

Nooshabadi

et al. 2018

JoVE

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The rapid development of new optical imaging techniques is dependent on the availability of low-cost, customizable, and easily reproducible standards. By replicating the imaging environment, costly animal experiments to validate a technique may be circumvented. Predicting and optimizing the performance of in vivo and ex vivo imaging techniques requires testing on samples that are optically similar to tissues of interest. Tissue-mimicking optical phantoms provide a standard for evaluation, characterization, or calibration of an optical system. Homogenous polymer optical tissue phantoms are widely used to mimic the optical properties of a specific tissue type within a narrow spectral range. Layered tissues, such as the epidermis and dermis, can be mimicked by simply stacking these homogenous slab phantoms. However, many in vivo imaging techniques are applied to more spatially complex tissue where three dimensional structures, such as blood vessels, airways, or tissue defects, can affect the performance of the imaging system. This protocol describes the fabrication of a tissue-mimicking phantom that incorporates three-dimensional structural complexity using material with optical properties of tissue. Look-up tables provide India ink and titanium dioxide recipes for optical absorption and scattering targets. Methods to characterize and tune the material optical properties are described. The phantom fabrication detailed in this article has an internal branching mock airway void; however, the technique can be broadly applied to other tissue or organ structures.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Durkee

Nash

Nooshabadi

et al. 2018

JoVE

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“…Optical characterization of breast phantom at NIR range shown similar curves of absorbance like human breast [1,2]. The elastic properties of breast tissue depend on the microscopic and macroscopic structural organization of their molecules [3].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Characterization of a Breast Phantom

Triana

Cristiano

Gutiérrez

et al. 2017

VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

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Abstract-A Breast Phantom is an appropriate way to study early detection of breast cancer because the Phantom let to model and perform experiments of mechanical and optical properties of the breast that are ethically impossible to do in a woman. In this paper, we report the mechanical characterization of a breast Phantom. The Phantom preparation was a water based solution and glycerine mixed with phenol and pectin. At the elaboration process, the mix proportions were modified seeking varied textures, colors, and form which simulated mechanics and optics properties a mammary tissue. Stress and deformation measurement were done to perform mechanic characterization. The elasticity module of refined and unrefined pectin Phantom was compared with breast fibrous and glandular tissues achieving values in the same range.

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“…But, it has also found important application as a phantom material in medical imaging and surgical-guidance studies (e.g. simulating breast, prostate and other tissues) (Lawrentschuk et al (2011);Lindner et al (2010); Maier-Hein et al (2009); Miranda et al (2013); März et al (2014); Sutcliffe et al (2013)), wherein it has been found to emulate soft tissue properties with satisfactory fidelity. It is these latter applications, in which loading speeds (that we loosely call 'surgical speeds') are several orders of magnitude lower than in ballistics studies, that motivate the present work.…”

Section: Introductionmentioning

confidence: 99%

A constitutive model for ballistic gelatin at surgical strain rates

Ravikumar

Noble

Cramphorn

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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This paper describes a constitutive model for ballistic gelatin at the low strain rates experienced, for example, by soft tissues during surgery. While this material is most commonly associated with high speed projectile penetration and impact investigations, it has also been used extensively as a soft tissue simulant in validation studies for surgical technologies (e.g. surgical simulation and guidance systems), for which loading speeds and the corresponding mechanical response of the material are quite different. We conducted mechanical compression experiments on gelatin specimens at strain rates spanning two orders of magnitude (∼ 0.001 − 0.1s −1 ) and observed a nonlinear load-displacement history and strong strain rate-dependence. A compact and efficient visco-hyperelastic constitutive model was then formulated and found to fit the experimental data well. An Ogden type strain energy density function was employed for the elastic component. A single Prony exponential term was found to be adequate to capture the observed rate-dependence of the response over multiple strain rates. The model lends itself to immediate use within many commercial finite element packages.

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Breast phantom for mammary tissue characterization by near infrared spectroscopy

Cited by 5 publications

References 2 publications

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Mechanical Characterization of a Breast Phantom

A constitutive model for ballistic gelatin at surgical strain rates

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