Breast reconstruction using autologous fat

Khonji, N.

doi:10.1002/bjs.7101

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Purified autologous fat has been used as a filler to contour deformities for several years. Coleman and colleagues devised the method used for most reconstructive purposes today ( Fig . ).…”

Section: Introductionmentioning

confidence: 99%

Lipotransfer for radiation-induced skin fibrosis

Kumar

Adigbli

Kalavrezos

et al. 2016

British Journal of Surgery

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Section: Introductionmentioning

confidence: 99%

Lipotransfer for radiation-induced skin fibrosis

Kumar

Adigbli

Kalavrezos

et al. 2016

British Journal of Surgery

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“…Autologous fat grafts enriched with ASCs are routinely used for reconstructive surgical procedures . There has been published clinical evidence demonstrating beneficial use of autologous fat for treatment of radiotherapy‐induced tissue damage .…”

Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow Cells

et al. 2019

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Radiation therapy to anatomic regions, including the head and neck, chest wall, and extremities, can produce radiation‐induced fibrosis (RIF). To elucidate the cellular and molecular mechanism(s) involved in RIF, female C57BL/6J mice were irradiated to the right flank to 35 Gy in single fraction using 6 Mv electrons. Radiation fibrosis was detected by day 14, was increased by day 28, and confirmed by Masson's trichrome histological staining for collagen. Biopsied tissue at day 14 showed an increase in expression of fibrosis‐related genes including transforming growth factor‐β (TGF‐β) and collagens 1–6. A single adipose‐derived stem cell (ASC) injection on day 28 at the irradiated site decreased by day 40: epithelial thickness, collagen deposition, and significantly improved limb excursion compared with irradiated controls. Noncontact transwell coculture of ASCs above a monolayer of irradiated human foreskin fibroblasts downregulated fibrosis‐related genes TGF‐β, connective tissue growth factor, interleukin‐1, NF‐kB, tumor necrosis factor, and collagens 1–6. Hepatocyte growth factor (HGF) secreted by ASCs was identified as a novel mechanism by which ASCs exert antifibrotic effects by downregulating fibrotic gene expression in irradiated cells and recruiting bone marrow cells to the irradiated site. In conclusion, these data indicate a mechanistic role of HGF secreted by ASCs in reducing RIF. Stem Cells 2019;37:791–802

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“…Autologous fat grafting has been widely used in many reconstructive surgeries, such as aesthetic skeletal remodeling, breast reconstruction, facial rejuvenation, and facial reconstruction [39]. FISH can be used to detect specific DNA or ribonucleic acid (RNA) sequences within the context of the cell.…”

Section: Reviewmentioning

confidence: 99%

Application of Fluorescence In Situ Hybridization (FISH) Technique for the Detection of Genetic Aberration in Medical Science

Ratan

Zaman

Team

et al. 2017

Cureus

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Fluorescence in situ hybridization (FISH) is a macromolecule recognition technique, which is considered as a new advent in the field of cytology. Initially, it was developed as a physical mapping tool to delineate genes within chromosomes. The accuracy and versatility of FISH were subsequently capitalized upon in biological and medical research. This visually appealing technique provides an intermediate degree of resolution between DNA analysis and chromosomal investigations. FISH consists of a hybridizing DNA probe, which can be labeled directly or indirectly. In the case of direct labeling, fluorescent nucleotides are used, while indirect labeling is incorporated with reporter molecules that are subsequently detected by fluorescent antibodies or other affinity molecules. FISH is applied to detect genetic abnormalities that include different characteristic gene fusions or the presence of an abnormal number of chromosomes in a cell or loss of a chromosomal region or a whole chromosome. It is also applied in different research applications, such as gene mapping or the identification of novel oncogenes. This article reviews the concept of FISH, its application, and its advantages in medical science.

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Breast reconstruction using autologous fat

Cited by 8 publications

References 10 publications

Lipotransfer for radiation-induced skin fibrosis

Lipotransfer for radiation-induced skin fibrosis

Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow Cells

Application of Fluorescence In Situ Hybridization (FISH) Technique for the Detection of Genetic Aberration in Medical Science

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