Breast tuberculosis

Sinha, Richa; Rahul, .

doi:10.1016/j.ijtb.2018.07.003

Cited by 13 publications

(56 citation statements)

References 27 publications

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“…extreme rarity (1,2). Although gold standard diagnostic modality of BTB is demonstration of acid fast bacilli (AFB) by microscopy and culture, histopathological evaluation showing caseating epithelioid granuloma is also diagnostic of BTB.…”

Section: International Journal Of Medical and Biomedical Studies (Ijmbs)mentioning

confidence: 99%

“…Tuberculosis is a global public health problem disease with extra-pulmonary form of tuberculosis accounting for only 18% of global prevalence. (1).Breast tuberculosis (BTB) is a very rare form of extra pulmonary tuberculosis (EPTB) persisting even today, since Sir Astley Cooper first described it in 1829. (1).The incidence of this rare clinical entity is less than 0.1% in developed countries and 3-4.5% of breast lesions in endemic countries like India.…”

Section: Introductionmentioning

confidence: 99%

“…(1).Breast tuberculosis (BTB) is a very rare form of extra pulmonary tuberculosis (EPTB) persisting even today, since Sir Astley Cooper first described it in 1829. (1).The incidence of this rare clinical entity is less than 0.1% in developed countries and 3-4.5% of breast lesions in endemic countries like India. (1)The incidence of EPTB is on the rise worldwide due to increasing prevalence of immunosuppressive diseases and multidrug resistance tuberculosis but still, BTB constitutes only 0.1% of EPTB.…”

Section: Introductionmentioning

confidence: 99%

“…(1).The incidence of this rare clinical entity is less than 0.1% in developed countries and 3-4.5% of breast lesions in endemic countries like India. (1)The incidence of EPTB is on the rise worldwide due to increasing prevalence of immunosuppressive diseases and multidrug resistance tuberculosis but still, BTB constitutes only 0.1% of EPTB. (2,3) The non-specific clinical and imaging characteristics and lack of familiarity of clinicians with this rare entity along with non-availability of confirmatory test have led to increased rates of underreporting and underdiagnoses.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically as it simulates with more common breast lesions such as breast carcinoma, pyogenic abscess, fibroadenoma, duct ectasia and other granulomatous and fungal diseases, it poses a diagnostic challenge. (1,2) Resistance of breast tissue to the survival and multiplication of tubercular bacilli may be the cause of this Dr Swagata.Brahmachari et al…”

Section: Introductionmentioning

confidence: 99%

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Breast Tuberculosis-a Rare Presentation of Common Disease With Diagnostic and Therapeutic Challenge.

Brahmachari

Nema

Padma

et al. 2020

IJMBS

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Background: Breast tuberculosis is a rare extra pulmonary tuberculosis presentation usually misdiagnosed as carcinoma, pyogenic abscess or idiopathic granulomatous mastitis. Detection of tubercular bacilli by ZN stain, culture and CBNAAT along with caseating granuloma on histopathology helps in diagnosis. Aims and Objectives: To study the clinico-pathological characteristic of breast tuberculosis and diagnostic accuracy of CBNAAT for early and specific diagnosis in reference to histopathological test Material and Methods: 38 cases of BTB between August2012 to July 2017 were studied. Culture for acid-fast bacilli, smear positivity on Z-N staining, CBNAAT, and cytological and histological examination was done for confirmation. Results: Prevalence of BTB in this study was found to be 3.95% .The risk factors were reproductive age (20-35), multiparity, lactation and low socioeconomic status. Unilateral lump in the upper outer and central quadrant of the breast was the commonest observation. Only 34.2% were diagnosed provisionally as BTB rest 73.68% were misdiagnosed as fibroadenoma, breast abscess and malignancy Clinically nodulo-caseous variety(55.6 %) disseminated (18.4%) and tubercular abscess (26.3%) were seen. Sensitivity of ZN staining, culture, FNAC and histopathology is 15.8%,5.8%, 74% ,100%respectively. Sensitivity, specificity, positive predictive value, and negative predictive value for the CBNAAT test were 81.818%, 93.103%, 93.10%, and 81.82% respectively.39.4% were cured completely with ATT with 60.52% with residual lesions needed surgery Conclusion: This study highlights the importance of early diagnosis and aggressive medical and if required surgical management to cure this disease. CBNAAT should be used as an additional test to conventional smear microscopy, culture, FNAC and histology. Keywords: Breast tuberculosis, CBNAAT, Extrapulmonary tuberculosis, breast lump

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Section: International Journal Of Medical and Biomedical Studies (Ijmbs)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Breast Tuberculosis-a Rare Presentation of Common Disease With Diagnostic and Therapeutic Challenge.

Brahmachari

Nema

Padma

et al. 2020

IJMBS

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2022

Breastfeeding

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Primary Breast Tuberculosis Mastitis Manifested as Nonhealing Abscess

et al. 2022

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Primary breast tuberculosis (TB) is a rare extrapulmonary TB mainly affecting young women of childbearing age from endemic countries. Its incidence is increasing in immunocompromised and HIV-infected people and with the emergence of drug-resistant strains of Mycobacterium tuberculosis (MTB). There are no specific clinical signs suggestive of this disease, it often presents as a hard mass or breast abscess. There is an overlap of features with other inflammatory, infectious, benign lesions, fat necrosis and malignant neoplasms of the breast. The detection of MTB remains the gold standard for diagnosis. Several other diagnostic modalities are used, with varying lack of sensitivity and specificity, and with a range of false negatives. A quarter of cases were treated solely on the basis of clinical, imaging or histological suspicion, without confirmation of the diagnosis. Therefore, we report the case of a young Vietnamese woman, presented for a nonhealing breast abscess, and diagnosed with breast TB based on the patient's ethnicity, histological findings, lack of clinical response to conventional antibiotic therapy, and a good clinical response to anti-TB treatment.

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Breast tuberculosis

Cited by 13 publications

References 27 publications

Breast Tuberculosis-a Rare Presentation of Common Disease With Diagnostic and Therapeutic Challenge.

Breast Tuberculosis-a Rare Presentation of Common Disease With Diagnostic and Therapeutic Challenge.

References

Primary Breast Tuberculosis Mastitis Manifested as Nonhealing Abscess

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