Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration

Lindberg, Lars; Brauer, Sandra G.; Wollmer, Per; Goldberg, Leonard; Jones, Alan Wayne; Olsson, Sven‐Gunnar

doi:10.1016/j.forsciint.2006.07.018

Cited by 97 publications

(86 citation statements)

References 23 publications

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“…One important feature of AAA models is the definition of biologically meaningful levels of alcohol, either in vitro or in vivo, and their relationship to blood alcohol levels (BAL) in humans. This is an important requirement of the research models of AAA, because BAL can be detected as soon as minimal amounts of alcohol are ingested [85] , however measurable affects of alcohol on physiology and/or behavior is established at 0.08% or above this level, with individual variations depending on the species, metabolic particularities, age, gender and genetic background [86][87][88][89][90][91][92][93][94][95][96][97] . It is also important to identify that AAA models differ by their route of alcohol delivery to achieve alcohol intoxication, some of them being physiological, such as oral administration, while others being non-physiological, when ethanol is administered by parenteral routes.…”

Section: Models Of Aaamentioning

confidence: 99%

In vitroandin vivomodels of acute alcohol exposure

Dolganiuc

Szabó

2009

WJG

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Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.

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Section: Models Of Aaamentioning

confidence: 99%

In vitroandin vivomodels of acute alcohol exposure

Dolganiuc

Szabó

2009

WJG

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“…6.1 software, a user-independentˆtting routine that uses a library of model spectra of all individual metabolites. 6 We used the original basis-set consisting of 28 model spectra of metabolites including ethanol (provided by S.W. Provencher).…”

Section: Methodsmentioning

confidence: 99%

“…[2][3][4][5] Although measurement of alcohol concentration in breath vapor is the most convenient method for determining alcohol concentration in the body, this method does not directly evaluate the concentration in the brain. 6 The most accurate determination of alcohol concentration in the body is direct measurement from the blood, but continuous measurement is invasive because recurrent blood sampling is required for every measurement.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument

et al. 2013

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Purpose: Our purposes were to establish suitable conditions for proton magnetic resonance spectroscopy (MRS) to measure dynamic changes in alcohol concentration in the human brain, to evaluate these changes, and to compare theˆndings with data from analysis of breath vapor and blood samples.Materials and Methods: We evaluated 4 healthy volunteers (mean age 26.5 years; 3 males, one female) with no neurologicalˆndings. All studies were performed with 3-tesla clinical equipment using an 8-channel head coil. We applied our modiˆed single-voxel point-resolved spectroscopy (PRESS) sequence. Continuous measurements of MRS, breath vapor, and blood samples were conducted before and after the subjects drank alcohol with a light meal. The obtained spectra were quantiˆed by LCModel Ver. 6.1, and the accuracy of the MRS measurements was estimated using the estimated standard deviation expressed in percentage (zSD) as a criterion.Results: Alcohol peaks after drinking were clearly detected at 1.2 ppm for all durations of measurement. Good correlations between breath vapor or blood sample and MRS were found by sub-minute MRS measurement. The continuous measurement showed timedependent changes in alcohol in the brain and various patterns that diŠered among subjects.Conclusions: The clinical 3T equipment enables direct evaluation of sub-minute changes in alcohol metabolism in the human brain.

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“…Finally, alcohol concentration was measured in expired breath and not with blood samples to avoid stress for subjects. However, many studies highlighted a high correlation between blood alcohol concentration and BrAC (Lindberg et al, 2007;Jaffe et al, 2013).…”

Section: Limitationsmentioning

confidence: 99%

Cardiovascular and cutaneous responses to the combination of alcohol and soft drinks: the way to orthostatic intolerance?

Maufrais¹

2017

http://isrctn.com/

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Aim: Acute ingestion of alcohol is often accompanied by cardiovascular dysregulation, malaise and even syncope. The full hemodynamic and cutaneous responses to the combination of alcohol and sugar (i.e., alcopops), a common combination in young people, and the mechanisms for the propensity to orthostatic intolerance are not well established. Thus, the purpose of this study was to evaluate the cardiovascular and cutaneous responses to alcopops in young subjects.Methods: Cardiovascular and cutaneous responses were assessed in 24 healthy young subjects (12 men, 12 women) sitting comfortably and during prolonged active standing with a 30-min baseline and 130 min following ingestion of 400 mL of either: water, water + 48 g sugar, water + vodka (1.28 mL.kg −1 of body weight, providing 0.4 g alcohol.kg −1 ), water + sugar + vodka, according to a randomized cross-over design.Results: Compared to alcohol alone, vodka + sugar induced a lower breath alcohol concentration (BrAC), blood pressure and total peripheral resistance (p < 0.05), a higher cardiac output and heart rate (p < 0.05) both in sitting position and during active standing. In sitting position vodka + sugar consumption also led to a greater increase in skin blood flow and hand temperature (p < 0.05) and a decrease in baroreflex sensitivity (p < 0.05). We observed similar results between men and women both in sitting position and during active standing.Conclusion: Despite lower BrAC, ingestion of alcopops induced acute vasodilation and hypotension in sitting position and an encroach of the hemodynamic reserve during active standing. Even if subjects did not feel any signs of syncope these results could be of clinical importance with higher doses of alcohol or if combined to other hypotensive challenges.

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Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration

Cited by 97 publications

References 23 publications

In vitroandin vivomodels of acute alcohol exposure

In vitroandin vivomodels of acute alcohol exposure

Preliminary Observation of Dynamic Changes in Alcohol Concentration in the Human Brain with Proton Magnetic Resonance Spectroscopy on a 3T MR Instrument

Cardiovascular and cutaneous responses to the combination of alcohol and soft drinks: the way to orthostatic intolerance?

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