2023
DOI: 10.1002/adma.202304903
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Breath Biopsy Reveals Systemic Immunothrombosis and Its Resolution through Bioorthogonal Dendritic Nanoprobes

Yuanlin Zhang,
Ehsan Ranaei Pirmardan,
Aliaa Barakat
et al.

Abstract: Immunothrombosis, an inflammation‐dependent activation of the coagulation cascade, leads to microthrombi formations in small vessels. It is a dreaded complication of COVID‐19 and a major cause of respiratory failure. Due to their size and disseminated nature, microthrombi are currently undetectable. Here, we introduce non‐invasive detection of a volatile reporter in the exhaled air for assessment of systemic immunothrombosis. A dendritic nanoprobe, containing high loading of a thrombin‐sensitive substrate, was… Show more

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