Breathing more breadth into COVID-19 T cell responses

Abstract

Innate and adaptive heterologous immunity confers resistance to pathogens. However, its impact on resistance and the course of human infection have remained largely elusive, hampering the use of this phenomenon to enhance vaccine efficacy. In this issue of Med, Mysore et al. show that T cell responses elicited by SARS-CoV-2 infection or vaccination correlate with those induced by MMR and Tdap immunization, revealing the transcriptomic basis of these correlations and find that heterologous adaptive immunity contributes to a better prognosis of COVID-19 disease. 1

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

“…Risk-benefit decisions in Flint, MI resulted in years of exposure of children and adults to the neurotoxic, microimmunosome-damaging, heavy metal Pb (lead). [4,49,50] Disowning fundamental immunology and the role of natural immunity during the SARS-CoV-2 pandemic and the importance of T cell responses to viruses in heterologous adaptive immunity [51][52][53]…”

“…As can be seen in Table 1 [ 3 , 4 , 9 , 10 , 13 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ], the danger in recent public health failures is not simply that time and money was expended in unsuccessfully combatting the NCD epidemic. It is that some of the recommendations actually further erode both the microbiome and human health.…”