Breckpot β‐Lactam Synthesis

Abstract

The synthesis of β‐lactam via the cyclization of esters of β‐amino acids with Grignard reagent and is known as the Breckpot β‐lactam synthesis. This reaction has been modified by using Mukaiyama's reagent or N ‐methyl pyridinium salt to convert the β‐amino acids into β‐lactams. This reaction has been used to synthesize β‐lactams such as azetidinone.