Bred to breed?! Implications of continuous mating on the emotional status of mouse offspring

Lerch, Sandra; Brandwein, Christiane; Dormann, Christof; Gass, Peter; Chourbaji, Sabine

doi:10.1016/j.bbr.2014.11.007

Cited by 8 publications

(2 citation statements)

References 49 publications

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“…For the subsequently conducted analysis of hippocampusand amygdala-associated emotional learning, the Fear Conditioning system was used (TSE Systems, Bad Homburg, Germany). The paradigm applied in our study comprised three days of exposition and was conducted as described earlier [22,23].…”

Section: Fear Conditioning and Hotplate Testmentioning

confidence: 99%

Mice age — Does the age of the mother predict offspring behaviour?

Lerch

Brandwein

Dormann

et al. 2015

Physiology & Behavior

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Section: Fear Conditioning and Hotplate Testmentioning

confidence: 99%

Mice age — Does the age of the mother predict offspring behaviour?

Lerch

Brandwein

Dormann

et al. 2015

Physiology & Behavior

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“…Such artificial weaning routines include mother-offspring separation at various time points between postnatal days 18 and 28, but mostly take place around postnatal day 21. This is mainly due to the fact that so-called ‘continuous mating strategies’ are adopted to maximize the breeding success and the productivity in big breeding units [11]. Here, mating takes place during postpartum oestrus, so that the following gestation period of about 21 days completely overlaps with raising the young of the previous litter.…”

Section: Introductionmentioning

confidence: 99%

A Time to Wean? Impact of Weaning Age on Anxiety-Like Behaviour and Stability of Behavioural Traits in Full Adulthood

et al. 2016

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In mammals, weaning constitutes an important phase in the progression to adulthood. It comprises the termination of suckling and is characterized by several changes in the behaviour of both mother and offspring. Furthermore, numerous studies in rodents have shown that the time point of weaning shapes the behavioural profile of the young. Most of these studies, however, have focused on ‘early weaning’, while relatively little work has been done to study ‘late weaning’ effects. The aim of the present study was therefore to explore behavioural effects of ‘late weaning’, and furthermore to gain insights into modulating effects of weaning age on the consistency of behavioural expressions over time. In total, 25 male and 20 female C57BL/6J mice, weaned after three (W3) or four (W4) weeks of age, were subjected to a series of behavioural paradigms widely used to assess anxiety-like behaviour, exploratory locomotion, and nest building performance. Behavioural testing took place with the mice reaching an age of 20 weeks and was repeated eight weeks later to investigate the stability of behavioural expressions over time. At the group level, W4 mice behaved less anxious and more explorative than W3 animals in the Open Field and Novel Cage, while anxiety-like behaviour on the Elevated Plus Maze was modulated by a weaning-age-by-sex interaction. Furthermore, weaning age shaped the degree of behavioural stability over time in a sex-specific way. While W3 females and W4 males displayed a remarkable degree of behavioural stability over time, no such patterns were observed in W3 males and W4 females. Adding to the existing literature, we could thus confirm that effects of weaning age do indeed exist when prolonging this phase, and were furthermore able to provide first evidence for the impact of weaning age and sex on the consistency of behavioural expressions over time.

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The laboratory mouse

Pritchett‐Corning,

Garner

2024

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

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Bred to breed?! Implications of continuous mating on the emotional status of mouse offspring

Cited by 8 publications

References 49 publications

Mice age — Does the age of the mother predict offspring behaviour?

Mice age — Does the age of the mother predict offspring behaviour?

A Time to Wean? Impact of Weaning Age on Anxiety-Like Behaviour and Stability of Behavioural Traits in Full Adulthood

The laboratory mouse

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