This article will give an in-depth analysis of our journey in decolonizing the archives of the London School of Hygiene & Tropical Medicine (LSHTM) which began in 2019 and is ongoing. It will give readers the opportunity to understand how an institution created by the Colonial Office is confronting its history and its colonial legacy, and how the Archives Service is changing its practices in a way that seeks to confront and disrupt the colonial narrative. This has been achieved through an overview of the colonial history of the School by a research fellow and the development of decolonizing principles covering cataloguing practice, archival practice, dissemination, education and inclusion.