Brief Commentary on the Article “Diagnostic Value of Plasma Pentraxin-3 in Acute Appendicitis”

Purpose To systematically summarize all relevant data and to define the current evidence on the utility of Pentraxin-3 (PTX3) as a biomarker for acute appendicitis (AA) in children. Methods This review was conducted in accordance with the PRISMA guidelines. PubMed, Embase, Scopus, and Web of Science databases were systematically searched for studies comparing the levels of PTX3 in patients with AA vs healthy controls or non-specific abdominal pain (NSAP). Mean differences were calculated for all outcomes and the inverse variance method was used for weighted mean difference. The methodological quality of the included studies was assessed using the Downs and Black scale. Results Five comparative studies were included. Significantly elevated levels of PTX3 in cases with AA vs healthy controls (WMD: 9.56, 95% CI 7.24–11.88, p < 0.00001), and patients with AA vs NSAP (WMD: 8.05, 95% CI 6.81–9.29, p < 0.00001) were demonstrated. Similarly, in separate meta-analyses, the levels of PTX3 were significantly elevated in children with AA vs healthy controls (WMD: 11.18, 95% CI 10.03–12.34, p < 0.00001), and children with AA vs NSAP (WMD: 8.35, 95% CI 6.88–9.82, p < 0.00001). Conclusions PTX3-levels are elevated in AA, but differentiation between perforated and non-perforated appendicitis demands other methods.

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“…1 ). Out of seven screened abstracts, one was excluded [ 10 ]. Only six full-texts were assessed for eligibility.…”

Section: Resultsmentioning

confidence: 99%

Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis

et al. 2022

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“…[1] On the other hand, the timely accurate diagnosis before the appendectomy is necessary because the prolonged diagnosis process puts the patient at risk of perforation, and specific for the diagnosis of AA. [2,7] CRP is also a widely used inflammatory marker and more specific than the WBC count. However, the diagnostic performance of the CRP for the determining severity of disease or complication is lower in the early phase of the infection because the elevation of CRP requires time approximately 48 hours or over.…”

Section: Introductionmentioning

confidence: 99%

“…Interleukin-6 is widely used in clinical intervention because it has both anti and pro-inflammatory properties. [7] Imaging techniques have improved accuracy for the diagnosis of AA, but the qualified personal for the US are not available in all health care institutions. The inability to visualize the normal appendix is considered a major weakness of using the US in examining patients with suspected AA.…”

Section: Introductionmentioning

confidence: 99%

Using Pentraxin-3 for diagnosing acute appendicitis and predicting perforation: A prospective comparative methodological study

Gul

Destek

2020

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:In this study, we aimed to investigate the diagnostic performance of pentraxin-3 for acute appendicitis, and the predictive performance for perforation in patients with acute appendicitis, compared with white blood cell count, high-sensitivity Creactive protein and interleukin-6 (IL-6). METHODS:This study was a prospective methodological study, in which we studied the accuracies of the serum levels of pentraxin-3, white blood cell count, interleukin-6 and high-sensitivity C-reactive protein in estimating acute appendicitis, and in estimating perforation in patients with acute appendicitis. We designed the control group with the patients diagnosed inguinal hernia and admitted for elective surgery. Receiver operating characteristics analysis was used to compare the diagnostic accuracies and predictive performances. RESULTS:Receiver operating characteristics analysis revealed that the Pentraxin-3 level >3.67 ng/mL showed the sensitivity of 95.5% and specificity of 100.0% for diagnosing acute appendicitis, with an area under the curve of 0.993 (95% CI 0.967-1.000). Also, the Pentraxin-3 level >9.56 ng/mL showed the sensitivity of 92.9%, and the specificity of 87.1% for the prediction of the perforation, with an area under the curve of 0.820 (95% CI 0.736-0.886). CONCLUSION:The diagnostic performance of Pentraxin-3 for acute appendicitis and the predictive performance for perforation were higher than white blood cell count, high-sensitivity C-reactive protein and interleukin-6.

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Serum pentraxin-3 in diagnosing acute appendicitis in patients with acute abdominal pain: A systematic review and meta-analysis of diagnostic test accuracy

Octavius

Muljono

Budiputri

2023

Surgery

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Brief Commentary on the Article “Diagnostic Value of Plasma Pentraxin-3 in Acute Appendicitis”

Cited by 3 publications

References 11 publications

Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis

Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis

Using Pentraxin-3 for diagnosing acute appendicitis and predicting perforation: A prospective comparative methodological study

Serum pentraxin-3 in diagnosing acute appendicitis in patients with acute abdominal pain: A systematic review and meta-analysis of diagnostic test accuracy

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