Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels

Abstract

Pupil mydriasis at scotopic illumination levels was reduced by both drugs in a similar fashion. Because of the slightly stronger effect of brimonidine, application of this agent 20 minutes before activities in dimly lit areas or at night may be recommended for photic phenomena following refractive surgery.

Aceclidine, brimonidine tartrate, and dapiprazole: Comparison of miotic effect and tolerability under different lighting conditions

“…However, the effect of dapiprazole 0.25% was not as long lasting as that of brimonidine tartrate 0.20%, with many eyes in the dapiprazole group having a pupil width similar to that at baseline after 4 hours. This is similar to the findings of Marx-Gross et al, 22 who compared the effects of brimonidine and dapiprazole on pupil size under various illumination levels, and to those of Kesler et al, 23 who found significant miosis after instillation of brimonidine tartrate 0.2% ophthalmic solution.…”

Effect of brimonidine tartrate 0.10% ophthalmic solution on pupil diameter

“…This is consistent with previous reports of brimonidine's effect on pupil diameter in concentrations of 0.15% and 0.20%. [7][8][9][10][11] Brimonidine has been suggested as an optional treatment to reduce night-vision disturbances after refractive surgery, which occur mainly in patients with large pupils, small optical treatment zones, and higher-order aberrations. 9,10 Brimonidine 0.10% seems to have the same antimydriatic effect as its higher concentrated solutions.…”

“…McDonald et al 6 showed that it causes a significant decrease in pupil diameter only in the dark. Subsequent studies have established that the reduction in pupil diameter induced by brimonidine 0.2% is significant under dark luminance conditions 7,8 and have suggested its use in reducing night-vision disturbances, such as glare and halos, after refractive surgery. 9 The same effect has been demonstrated with the use of brimonidine 0.15%.…”

“…10,11 A previous study by our group has shown that the effect on pupil diameter is more pronounced in light irides. 7 Some studies [5][6][7][8][9] refer to the decrease in pupil diameter as a miotic effect. Brimonidine's a2-agonistic activity decreases the production, storage, and release of norepinephrine into synapses.…”

Effects of brimonidine timolol fixed combination therapy on anterior ocular segment configuration

“…Measurements were done 1 h after dosing. Marx-Gross et al [4] report that the maximum miotic effect of brimonidine was seen after 40 min and remained stable 180 min after dosing. Consequently, we tested the effects of the eyedrops 1 h after administration of the medication.…”