2023
DOI: 10.1101/2023.01.20.524996
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Broadly Neutralizing Antibody Epitopes on HIV-1 Particles are exposed after Virus Interaction with Host Cells

Abstract: HIV-1 envelope glycoproteins (Env) are critical for infection and are key targets for vaccine development. Env proteins displayed on virions are conformationally diverse, comprising both functional and non-functional forms. These heterogeneous Env populations have important implications for neutralizing and non-neutralizing antibody elicitation and functions. This study aimed to interrogate the antigenic composition of Env on virions. Using a flow cytometry-based assay we show that only some epitopes including… Show more

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