Broccoli ameliorate NAFLD by increasing lipolysis and promoting liver macrophages polarize toward M2-type

Huang, Xiao Ping; Xu, Jia; Hu, Yingxin; Huang, Kunlun; Luo, Yunbo; He, Xiaoyun

doi:10.1016/j.jff.2021.104898

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Therefore, looking for drug substitutes with low side effects has become the focus of research worldwide, and some natural active ingredients in plants have been shown to alleviate NAFLD. For example, lupine peptide can repair HFD-induced liver injury by altering hepatic lipid signaling pathway [ 20 ], polyphenols of Raw Bowl tea can prevent NAFLD by regulating intestinal function in mice [ 12 ], and the water extract of broccoli can increase lipolysis and regulate M1/M2 polarization of macrophages to ameliorate NAFLD [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

Meng

Zhao

Chen

et al. 2022

Foods

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Non-alcoholic fatty liver disease (NAFLD) is one of the chronic liver diseases with high incidence in the world. This study aimed to investigate whether total flavonoids from Chimonanthus nitens Oliv. leaves (TFC) can ameliorate NAFLD. Herein, a high-fat diet (HFD)-induced NAFLD mice model was established, and TFC was administered orally. The results showed that TFC reduced the body weight and liver index and decreased the serum and hepatic levels of triglyceride (TG) and total cholesterol (TC). TFC significantly reduced the activity of liver functional transaminase. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) decreased by 34.61% and 39.57% in serum and 22.46% and 40.86% in the liver, respectively. TFC regulated the activities of oxidative-stress-related enzymes and upregulated the protein expression of nuclear factor E2-related factor (Nrf2)/heme oxygenase (HO-1) pathway in NAFLD mice, and the activities of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-PX) in serum were increased by 89.76% and 141.77%, respectively. In addition, TFC reduced the levels of free fatty acids (FFA), endotoxin (ET), and related inflammatory factors in mouse liver tissue and downregulated the expression of proteins associated with inflammatory pathways. After TFC treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β in the liver tissues of NAFLD mice were downregulated by 67.10%, 66.56%, and 61.45%, respectively. Finally, TFC reduced liver fat deposition, oxidative stress, and inflammatory response to repair liver damage and alleviate NAFLD. Further studies showed that TFC regulated the expression of intestinal-barrier-related genes and improved the composition of gut microbiota. Therefore, TFC reduced liver inflammation and restored intestinal homeostasis by regulating the gut–liver axis. Overall, our findings revealed a novel function of TFC as a promising prophylactic for the treatment of NAFLD.

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Section: Introductionmentioning

confidence: 99%

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

Meng

Zhao

Chen

et al. 2022

Foods

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Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats

Taher

El-Sammad

Mousa

et al. 2023

Preprint

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The high prevalence of non-alcoholic fatty liver disease (NAFLD) around the world presents a new challenge to modern medicine. Hence, this study was conducted to investigate the protective potential of Ficus lyrata Wrab bark extract on a high-fat diet (HFD)-induced NAFLD in a rat model. Male Wistar rats were fed a normal diet, or HFD, for 12 weeks. The HFD-rats were treated with F. lyrata extract (250 mg/kg, 5 days/week) or simvastatin (4 mg/kg, 5 days/week) from the fifth week until the twelfth week. At the end of the experiment, serum and liver were harvested. The results of biochemical, molecular, histopathological and immunohistochemical investigations were assessed. Oral administration of F. lyrata extract to HFD-fed rats for eight consecutive weeks reduced body and liver weights, improved serum lipid profile, aminotransferases, adipokines, and decreased hyperglycemia and hyperinsulinemia. The F. lyrata extract also reduced the expression of hepatic lipogenic genes (SREBP-1c, ACC-1, and FAS) and inflammatory markers (TNF-α and IL-6), while modulating oxidative stress and reversing histopathological changes. Our findings imply that F. lyrataextract is a promising therapeutic approach for hepatic steatosis and associated metabolic diseases.

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Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Ouyang

Zhu

2023

Front. Pharmacol.

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MAFLD stands for metabolic-related fatty liver disease, which is a prevalent liver disease affecting one-third of adults worldwide, and is strongly associated with obesity, hyperlipidemia, and type 2 diabetes. It encompasses a broad spectrum of conditions ranging from simple liver fat accumulation to advanced stages like chronic inflammation, tissue damage, fibrosis, cirrhosis, and even hepatocellular carcinoma. With limited approved drugs for MAFLD, identifying promising drug targets and developing effective treatment strategies is essential. The liver plays a critical role in regulating human immunity, and enriching innate and adaptive immune cells in the liver can significantly improve the pathological state of MAFLD. In the modern era of drug discovery, there is increasing evidence that traditional Chinese medicine prescriptions, natural products and herb components can effectively treat MAFLD. Our study aims to review the current evidence supporting the potential benefits of such treatments, specifically targeting immune cells that are responsible for the pathogenesis of MAFLD. By providing new insights into the development of traditional drugs for the treatment of MAFLD, our findings may pave the way for more effective and targeted therapeutic approaches.

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Broccoli ameliorate NAFLD by increasing lipolysis and promoting liver macrophages polarize toward M2-type

Cited by 3 publications

References 42 publications

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

Ficus Lyrata Bark Extract Alleviates Steatosis in Obesity- Induced Non-Alcoholic Fatty Liver Disease in Rats

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

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