Broccoli ingestion increases the glucosinolate hydrolysis activity of microbiota in the mouse gut

Wu, Yuanfeng; Shen, Yuke; Zhu, Yuezhao; Mupunga, Jothame; Zou, Lina; Liu, Chao; Liu, Shiwang; Mao, Jianwei

doi:10.1080/09637486.2018.1554624

Cited by 40 publications

(43 citation statements)

References 35 publications

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“…The amine can serve as a nitrogen source (Welte, et al., 2016) as well as a carbon and energy source (Hacisalihoglu et al., 1997) and can thus further promote bacterial growth. Plant defensive compounds including glucosinolates can influence the composition of gut microbial communities in insects and mammals (Wu et al., 2019; Zhang et al., 2020). Since ITCs show antibacterial activity, they could function to eliminate sensitive microorganisms from the insect’s gut and provide a more selective environment for the growth of ITC‐resistant and ITC‐degrading bacteria that may be acquired from host plants.…”

Section: Discussionmentioning

confidence: 99%

“…and can thus further promote bacterial growth. Plant defensive compounds including glucosinolates can influence the composition of gut microbial communities in insects and mammals(Wu et al, 2019;Zhang et al, 2020). Since ITCs show antibacterial activity, they could function to eliminate sensitive microorganisms from the insect's gut and provide a more selective environment for the growth of ITC-resistant and ITC-degrading bacteria that may be acquired from host plants.Reinfection with a single Pantoea isolate was sufficient to significantly reduce the ITC concentration in the feces of antibiotic-fed beetles.…”

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confidence: 99%

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Gut microbiota degrades toxic isothiocyanates in a flea beetle pest

Shukla

Beran

2020

Molecular Ecology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Gut microbiota degrades toxic isothiocyanates in a flea beetle pest

Shukla

Beran

2020

Molecular Ecology

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“…We also reported that the proportion of Desulfovibrionaceae [upper taxa (family) of Desulfobivrio ] was positively correlated with blood LPS levels, and that ingestion of broccoli sprout extract reduced Desulfovibrionaceae in cecal contents. Subsequently, Wu et al also reported that broccoli powder reduced the proportion of Desulfovibrio in the large intestinal contents of mice [167]. They reported that the decrease in Desulfovibrio composition was negatively correlated with the activity of myrosinase-like activity, isothiocyanate content, and NAD(P)H:quinone dehydrogenase 1 (NQO1) in the colonic mucosa.…”

Section: Association Of Dietary Factor-induced Reduction Of Blood mentioning

confidence: 99%

Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

Fuke¹,

Nagata

Suganuma³

et al. 2019

Nutrients

185

127

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Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are elevated, regardless of the presence of obvious infection. It has been suggested to lead to chronic inflammation-related diseases such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), pancreatitis, amyotrophic lateral sclerosis, and Alzheimer’s disease. In addition, it has attracted attention as a target for the prevention and treatment of these chronic diseases. As metabolic endotoxemia was first reported in mice that were fed a high-fat diet, research regarding its relationship with diets has been actively conducted in humans and animals. In this review, we summarize the relationship between fat intake and induction of metabolic endotoxemia, focusing on gut dysbiosis and the influx, kinetics, and metabolism of LPS. We also summarize the recent findings about dietary factors that attenuate metabolic endotoxemia, focusing on the regulation of gut microbiota. We hope that in the future, control of metabolic endotoxemia using dietary factors will help maintain human health.

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“…Tremendous evidence has indicated that F&V have manipulating effects on gut microbiota via in vivo and in vitro studies, in animal models or among human volunteers (Klinder et al, 2016;Zhu et al, 2016;Henning et al, 2017;Vivarelli et al, 2017;Choi et al, 2018;Marungruang et al, 2018;Cui et al, 2019;Nagano & Yano, 2019;Wu et al, 2019aWu et al, , 2019bWu et al, , 2019cWu et al, , 2019d. Subsequently, more in-depth investigations on phytochemicals have been carried out, and its correlation with gut microbiota has been explored extensively in recent years (Liu et al, 2018b;Liu et al, 2018a;Pansai et al, 2019;Wei et al, 2019;Wu et al, 2019;Xu et al, 2020;Zhou et al, 2020) (Table 1).…”

Section: Gut Microbiota Modulators In Fandvmentioning

confidence: 99%

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Lin

Bordiga

Brennan

et al. 2021

Int J of Food Sci Tech

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The objective of the current review was to systematically investigate health-promoting manipulating effects of fruits and vegetables (F&V) on the gut microbiota. The function of gut microbes was found to promote health effects in the host by scavenging free radicals, modulating immune system, alleviating obesity and diabetes. Masters that manipulate the gut microbiota are the phytochemicals within specific types of F&V, where polyphenols account for the largest proportion, along with alkaloids, terpenes, nitrogen-containing compounds, polysaccharides and natural pigments present in plants. These bioactive compounds exhibit the regulative influences on gut microorganisms characterised by rescuing dysbiosis of gut microbiota, increasing/decreasing microbial abundance, restructuring microbial composition, and rebalancing gut microbial homeostasis. This review indicated that F&V extracts targeting at gut microbiota could be a new scope of ingredient selection in the field of functional food especially for amelioration of dysfunction of intestinal ecosystem.

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Broccoli ingestion increases the glucosinolate hydrolysis activity of microbiota in the mouse gut

Cited by 40 publications

References 35 publications

Gut microbiota degrades toxic isothiocyanates in a flea beetle pest

Gut microbiota degrades toxic isothiocyanates in a flea beetle pest

Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

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