Bromocriptine in affective disorders

Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

“…High-dose bromocriptine has been reported to have antidepressant effects in numerous studies (Agnoli et al 1977;Colonna et al 1979;Ose 1980;Nordin et al 1981 ;Waehrens and Gerlach 1981) as well as an antimanic effect in one study (Dorr and Sathananthan 1976), but not in another (Smith et al 1980), so it is possible that what we observed in our patient was only in antidepressant action. However, the impressive and rapid change in psychotic symptoms after bromocriptine on two occasions indicates that more than an antidepressant action was involved.…”

Trajectories of depressive symptoms, dopamine D2 and D4 receptors, family socioeconomic status and social support in adolescence and young adulthood

“…Clinical studies have shown antidepressant effects of dopamine agonists including piribedil (Post et al, 1978) and bromocriptine (Colonna et al, 1979;Nordin et al, 1981;Silverstone, 1984), and dopamine uptake inhibitors such as nominfesine (Vanscheyen et al, 1977), bupropion (Feighner et al, 1984), minaprine (Amsterdam et al, 1989), and amineptine (Rampello et al, 1991). In contrast, dopamine receptor antagonists enhance the depression-like symptoms (Mann and Kapur, 1995).…”

Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice

“…It has been reported that DA receptor agonists, including D 2 agonists, enhance antidepressant effects of animals in the FST (Joca et al 2000;Maj and Rogoz 1999). Moreover, DA D 2 receptor agonists such as bromocriptine show an antidepressant effect in humans (Colonna et al 1979;Shopsin and Gershon 1978).…”