Bromophenols in Marine Algae and Their Bioactivities

Abstract

Marine algae contain various bromophenols that have been shown to possess a variety of biological activities, including antioxidant, antimicrobial, anticancer, anti-diabetic, and anti-thrombotic effects. Here, we briefly review the recent progress of these marine algal biomaterials, with respect to structure, bioactivities, and their potential application as pharmaceuticals.

Synthesis and paroxonase activities of novel bromophenols

“…Recent studies revealed that the marine bromophenols exhibit a wide spectrum of beneficial biological activities 2 . These compounds have attracted much attention in the field of functional food and pharmaceutical agents 2 .…”

“…Recent studies revealed that the marine bromophenols exhibit a wide spectrum of beneficial biological activities 2 . These compounds have attracted much attention in the field of functional food and pharmaceutical agents 2 . It has been reported that naturally occurring bromophenol 1 shows enzyme inhibition 3 , cytotoxicity 4 , feeding deterrent 5 , anti-microbial 6 , anti-cancer 7 and anti-oxidant 8 activities.…”

Α-Glucosidase INHIBITORY EFFECT OF SULOCHRIN FROM ASPERGILLUSTERREUS AND ITSBROMINATED DERIVATIVES

“…This finding is similar to that of Kim et al (2008) which showed that two bromophenol isolated from G. elliptica: 2,4,6-tribromophenolresulted in a higher inhibitory activity than 2,4-dibromophenolagainst yeastα-glucosidase. Liu et al(2011), also reported that the activity of bromophenol has a close relationship with the Br and phenolic unit in the molecule, for example, 3-bromo-4,5-dihydroxybenzyl alcohol inhibits against α-glucosidase with IC 50 of 100 μM, when one more position is brominated, the IC 50 value decreases to 89 μM.So it can be assumed that the inhibitory activity of bromophenol increases with the degree of bromo-substitution per benzene ring. To the best of our knowledge, this is the first report of identifying α-glucosidase inhibitory activity of sulochrin from A. terreusas well as dibromo-and tribromo derivative of sulochrin.…”

Evaluation of antioxidant activity and total phenol content of Gracilaria bursa-pastoris harvested in Nador lagoon for an enhanced economic valorization

“…On the other side, some authors have found other special bioactive compounds such as alkaloids, terpenes, bromophenols, phlorotannins, ascorbic acid, tocopherols, and carotenoids, in algae which have antioxidant potential [8][9][10][11][12][13]. These observations suggest that these bioactive compounds can have strong antioxidant properties.…”