Bronchiectasis: Retrospective Study And Risk Factors For Hospitalization

Ladeira, Inês; Ribeiro, Carla; Pascoal, Ivone; Taveira, Natália

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6094

Cited by 3 publications

(5 citation statements)

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“…Upon further review, 6201 abstracts or articles were rejected for meeting the study exclusion criteria (design not an observational study or no non‐cystic fibrosis bronchiectasis patients enrolled). Of the 306 full‐text articles reviewed at Level II screening, 54 reported on aetiologies of bronchiectasis . The reference lists of included studies were manually reviewed for identification of relevant articles that were not identified from the initial search.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Table S1 in the Supplementary Information, 24 studies (42.9%) analysed were prospective cohort studies; 19 (33.9%) were retrospective cohort studies; 7 (12.5%) were case‐control studies and six (10.7%) were cross‐sectional . The number of bronchiectasis patients ranged from 20 to 1258, and the mean age ranged from 42 to 73 years.…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of the identified aetiologies ranged from 18% to 95%. Geographically, 62.5% of aetiologies ( n = 35) were reported in studies conducted in Europe, 14.3% ( n = 8) in Asia, six in Oceania (Australia), five in South America (Brazil), one in North America (USA) and one in Africa (Tunisia)…”

Section: Resultsmentioning

confidence: 99%

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Aetiology of bronchiectasis in adults: A systematic literature review

et al. 2016

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While identifying the underlying aetiology is a key part of bronchiectasis management, the prevalence and impact of identifying the aetiologies on clinical management remain unclear. We aimed to determine the etiological spectrum of bronchiectasis, and how often etiological assessment could lead to the changes in patients' management. A comprehensive search was conducted using MEDLINE (via PubMed) and EMBASE for observational studies published before October 2015 reporting aetiologies in adults with bronchiectasis. Of the 8216 citations identified, 56 studies including 8608 adults with bronchiectasis were relevant for this systematic review. The crude prevalence for the identified aetiologies ranged from 18% to 95%, which possibly resulted from the differences in the geographic regions and diagnostic workup. Post-infective (29.9%), immunodeficiency (5%), chronic obstructive pulmonary disease (3.9%), connective tissue disease (3.8%), ciliary dysfunction (2.5%), allergic bronchopulmonary aspergillosis (2.6%) were the most common aetiologies. In 1577 patients (18.3%), identifying the aetiologies led to changes in patient's management. Aetiologies varied considerably among different geographic regions (P < 0.001). Intensive investigations of these aetiologies might help change patient's management and therefore should be incorporated into routine clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Aetiology of bronchiectasis in adults: A systematic literature review

et al. 2016

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“…Some epidemiological information comes from papers that, despite having other aims, describe adult bronchiectasis populations and briefly their aetiologies, including ciliary dysfunction [ 61 – 68 ].…”

Section: Prevalence Of Pcd In Adults With Bronchiectasismentioning

confidence: 99%

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

Contarini

Shoemark

Rademacher

et al. 2018

Multidiscip Respir Med

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Bronchiectasis represents the final pathway of several infectious, genetic, immunologic or allergic disorders. Accurate and prompt identification of the underlying cause is a key recommendation of several international guidelines, in order to tailor treatment appropriately. Primary ciliary dyskinesia (PCD) is a genetic cause of bronchiectasis in which failure of motile cilia leads to poor mucociliary clearance. Due to poor ciliary function in other organs, individuals can suffer from chronic rhinosinusitis, otitis media and infertility.This paper explores the current literature describing why, when and how to investigate PCD in adult patients with bronchiectasis. We describe the main PCD diagnostic tests and compare the two international PCD diagnostic guidelines. The expensive multi-test diagnostic approach requiring a high level of expertise and specialist equipment, make the multifaceted PCD diagnostic pathway complex. Therefore, the risk of late or missed diagnosis is high and has clinical and research implications.Defining the number of patients with bronchiectasis due to PCD is complex. To date, few studies outlining the aetiology of adult patients with bronchiectasis conduct screening tests for PCD, but they do differ in their diagnostic approach. Comparison of these studies reveals an estimated PCD prevalence of 1–13% in adults with bronchiectasis and describe patients as younger than their counterparts with moderate impairment of lung function and higher rates of chronic infection with Pseudomonas aeruginosa.Diagnosing PCD has clinical, socioeconomic and psychological implications, which affect patients’ life, including the possibility to have a specific and multidisciplinary team approach in a PCD referral centre, as well as a genetic and fertility counselling and special legal aspects in some countries.To date no specific treatments for PCD have been approved, standardized diagnostic protocols for PCD and recent diagnostic guidelines will be helpful to accurately define a population on which planning RCT studies to evaluate efficacy, safety and accuracy of PCD specific treatments.

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“…Defining the prevalence of PCD in adults with bronchiectasis is challenging. Some epidemiological information comes from papers that, despite having other aims, describe adult bronchiectasis populations and briefly their aetiologies, including ciliary dysfunction [61][62][63][64][65][66][67][68].…”

Section: Prevalence Of Pcd In Adults With Bronchiectasismentioning

confidence: 99%

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

et al. 2019

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Bronchiectasis represents the final pathway of several infectious, genetic, immunologic or allergic disorders. Accurate and prompt identification of the underlying cause is a key recommendation of several international guidelines, in order to tailor treatment appropriately. Primary ciliary dyskinesia (PCD) is a genetic cause of bronchiectasis in which failure of motile cilia leads to poor mucociliary clearance. Due to poor ciliary function in other organs, individuals can suffer from chronic rhinosinusitis, otitis media and infertility. This paper explores the current literature describing why, when and how to investigate PCD in adult patients with bronchiectasis. We describe the main PCD diagnostic tests and compare the two international PCD diagnostic guidelines. The expensive multi-test diagnostic approach requiring a high level of expertise and specialist equipment, make the multifaceted PCD diagnostic pathway complex. Therefore, the risk of late or missed diagnosis is high and has clinical and research implications. Defining the number of patients with bronchiectasis due to PCD is complex. To date, few studies outlining the aetiology of adult patients with bronchiectasis conduct screening tests for PCD, but they do differ in their diagnostic approach. Comparison of these studies reveals an estimated PCD prevalence of 1–13% in adults with bronchiectasis and describe patients as younger than their counterparts with moderate impairment of lung function and higher rates of chronic infection with Pseudomonas aeruginosa. Diagnosing PCD has clinical, socioeconomic and psychological implications, which affect patients’ life, including the possibility to have a specific and multidisciplinary team approach in a PCD referral centre, as well as a genetic and fertility counselling and special legal aspects in some countries. To date no specific treatments for PCD have been approved, standardized diagnostic protocols for PCD and recent diagnostic guidelines will be helpful to accurately define a population on which planning RCT studies to evaluate efficacy, safety and accuracy of PCD specific treatments.

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Bronchiectasis: Retrospective Study And Risk Factors For Hospitalization

Cited by 3 publications

References 0 publications

Aetiology of bronchiectasis in adults: A systematic literature review

Aetiology of bronchiectasis in adults: A systematic literature review

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

Why, when and how to investigate primary ciliary dyskinesia in adult patients with bronchiectasis

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