Bronchoalveolar lavage fluid alteration in antioxidant and inflammatory status in lung cancer patients

Kontakiotis, Theodoros; Katsoulis, K.; Hagizisi, O.; Kougioulis, M.; Gerou, Spyridon; Papakosta, Despina

doi:10.1016/j.ejim.2011.02.024

Cited by 17 publications

(6 citation statements)

References 19 publications

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“…In addition, they found a substantial 2.7-fold increase in glutathione in ELF from smokers with non-small cell lung cancer compared to the disease-free smokers. Similarly, Kontakiotis et al, (Kontakiotis et al 2011) found a 1.6-fold increase in glutathione in ELF in lung cancer patients compared to healthy controls.…”

Section: Lung Cancermentioning

confidence: 77%

Glutathione levels in human tumors

et al. 2012

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This review summarizes clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer. Glutathione tends to be elevated in breast, ovarian, head and neck and lung cancer and lower in brain and liver tumors compared to disease-free tissue. Cervical, colorectal, gastric and esophageal cancers show both higher and lower levels of tumor glutathione. Some studies show an inverse relationship between patient survival and tumor glutathione. Based on this survey, we recommend approaches that may improve the clinical value of glutathione as a biomarker.

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Section: Lung Cancermentioning

confidence: 77%

Glutathione levels in human tumors

et al. 2012

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“…17 Alteration in antioxidant status caused by increased oxidant burden can be assessed by measuring TAS. More recent studies assessing TAS levels in chronic diseases (lung cancer 31 and chronic adenotonsillitis 32 ) revealed that TAS levels were all high in the study groups. We concluded that increased TAS may represent an adaptive response of the tissue to this chronic oxidative stress in an attempt to neutralize the oxidative burden.…”

Section: Discussionmentioning

confidence: 89%

Oxidative Stress and Nasal Polyposis: Does it Affect the Severity of the Disease?

Topal

Kulaksızoğlu

Erbek

2014

Am J Rhinol�Allergy

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“…Therefore, our finding suggested possible biological interactions between chemokines and excessive formation of free radicals in response to xenobiotic insults. One previous study found that TAS was positively correlated with proinflammatory cytokines IL-1 α , IL-6, and TNF- α in bronchoalveolar lavage fluid in lung cancer patients [34]. It implicated that the interactions between chemokines and TAS might further contribute to the pathogenesis of human disease.…”

Section: Discussionmentioning

confidence: 99%

Positive Relationship between Total Antioxidant Status and Chemokines Observed in Adults

Browne

Bonner

et al. 2014

Oxidative Medicine and Cellular Longevity

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Objective. Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults. Methods. We assessed cross-sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL-1 (GRO-α), CXCL-8 (IL-8), CXCL-10 (IP-10), CCL-2 (MCP-1), CCL-5 (RANTES), CCL-8 (MCP-2), CCL-11 (Eotaxin-1), and CCL-17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics. Results. TAS showed significantly positive correlations with MCP-1 (r = 0.15751, P = 0.0014), MCP-2 (r = 0.3721, P = 0.0001), Eotaxin-1 (r = 0.39598, P < 0.0001), and TARC (r = 0.27149, P = 0.0053). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers. Conclusion. Total antioxidant status is positively associated with several chemokines in this adult population.

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Bronchoalveolar lavage fluid alteration in antioxidant and inflammatory status in lung cancer patients

Cited by 17 publications

References 19 publications

Glutathione levels in human tumors

Glutathione levels in human tumors

Oxidative Stress and Nasal Polyposis: Does it Affect the Severity of the Disease?

Positive Relationship between Total Antioxidant Status and Chemokines Observed in Adults

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