1985
DOI: 10.1136/bmj.291.6500.923
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Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction.

Abstract: Bronchoalveolar lavage performed in 10 patients with extrinsic asthma and 14 controls yielded similar recoveries of fluid and cells. Mast cells and eosinphils, however, formed a greater proportion of the cells recovered from the asthmatic subjects (p Show more

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Cited by 245 publications
(95 citation statements)
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“…Reintroduction of IgE to the sensitised cells promptly recommences signalling, suggesting that bound IgE does not prevent ''free'' IgE signalling [21]. These observations, therefore, provide a further mechanism for the enhanced constitutive mediator release evident in mast cells obtained from asthmatic versus normal subjects [28]. It is also of note that the top concentration of IgE studied, 3 mg?mL -1 , is equivalent to ,1250 iU?mL -1 , well within the range experienced in vivo.…”
Section: Discussionmentioning
confidence: 71%
“…Reintroduction of IgE to the sensitised cells promptly recommences signalling, suggesting that bound IgE does not prevent ''free'' IgE signalling [21]. These observations, therefore, provide a further mechanism for the enhanced constitutive mediator release evident in mast cells obtained from asthmatic versus normal subjects [28]. It is also of note that the top concentration of IgE studied, 3 mg?mL -1 , is equivalent to ,1250 iU?mL -1 , well within the range experienced in vivo.…”
Section: Discussionmentioning
confidence: 71%
“…Mast cells comprise approximately 0.25% of the total nucleated celis in the lavage fluid of normal individuals and these cells release histamine in dosedependent fashion on challenge with anti-IgE (5). Most interestingly, increased numbers of eosinophils and mast cells are recovered by lavage of asthmatic subjects and the latter cells show both a high deqree of spontaneous instability and an enhanced responsiveness to immunological challenge (7). There is also a significant correlation between the per~entage of mast cells in the lavage fluid of asthmatics and measured indices of airflow obstruction (7).…”
Section: Inflammatory Cells and Mediators In Asthma Fl Pearce Deparmentioning
confidence: 78%
“…Most interestingly, increased numbers of eosinophils and mast cells are recovered by lavage of asthmatic subjects and the latter cells show both a high deqree of spontaneous instability and an enhanced responsiveness to immunological challenge (7). There is also a significant correlation between the per~entage of mast cells in the lavage fluid of asthmatics and measured indices of airflow obstruction (7). In addition to histamine, anti-IgE induces a dosedependent release of the neWly generated mediators prostaglandin D 2 (PGD 2 ) and leukotrieneC 4 (LTC 4 ) from both BAL cells and parenchymal cells obtained by enzymic dispersion of whole lung tissue (6).…”
Section: Inflammatory Cells and Mediators In Asthma Fl Pearce Deparmentioning
confidence: 99%
See 1 more Smart Citation
“…The number of mast cells has been shown to be elevated in ASM tissues of asthmatics compared to nonasthmatic subjects with or without other inflammatory disorders (31). The participation of mast cells in AHR has been suggested based on correlations observed between the percentage of mast cells recovered in the bronchoalveolar lavage fluid (BALF) (64) or interspersed in the ASM tissue (113) and the degree of airway responsiveness. Interestingly, the later correlation was even stronger when the mast cells with a fibroblastoid phenotype, which spontaneously produce more histamine, were counted (113).…”
Section: Inflammatory Cells and Moleculesmentioning
confidence: 99%