2016
DOI: 10.1016/j.resp.2015.09.014
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Bronchoconstriction induced by inhaled methacholine delays desflurane uptake and elimination in a piglet model

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Cited by 7 publications
(16 citation statements)
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“…The situation in mice is also complicated by the fact that mouse FcγRIV acts as IgE-receptor similar to human FcεRI and contributes in IgE-induced lung inflammation [3]. More rarely, other allergy models than mice were used, for instance rats and guinea pigs [4,5], or piglets [6], especially for answering pharmacologic questions. In the investigated time period of this review (18 months back), no research articles involving monkey or nonhuman primates were published.…”
Section: Introductionmentioning
confidence: 99%
“…The situation in mice is also complicated by the fact that mouse FcγRIV acts as IgE-receptor similar to human FcεRI and contributes in IgE-induced lung inflammation [3]. More rarely, other allergy models than mice were used, for instance rats and guinea pigs [4,5], or piglets [6], especially for answering pharmacologic questions. In the investigated time period of this review (18 months back), no research articles involving monkey or nonhuman primates were published.…”
Section: Introductionmentioning
confidence: 99%
“…The present experimental design, materials and methods are in accordance with the corresponding experiment on the effects of MCh inhalation on desflurane pharmacokinetics [1] . It was scheduled as a prospective, controlled, animal trial in a single cohort of juvenile piglets.…”
Section: Experimental Design Materials and Methodsmentioning
confidence: 99%
“…Data analysis was performed with the Statistical Package for the Social Sciences (SPSS, v. 22, IBM Corporation, Armonk, New York, USA) and SigmaPlot® v. 11 (Systat Software Inc., San Jose, CA, USA). The estimation of sample size was based on previous experimental studies, which used an analogous experimental setup [1] , [10] , [11] , [12] . Power calculation using a two-sided design at a significance level of 5% ( α =0.05) and a power of 80% ( β =0.20) revealed that at least 4 animals per group were needed to detect a difference of more than 20% in the time to P90 arterial desflurane concentrations during MCh inhalation [1] .…”
Section: Experimental Design Materials and Methodsmentioning
confidence: 99%
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