Bronchopulmonary dysplasia

Kinsella, John P.; Greenough, Anne; Abman, Steven H.

doi:10.1016/s0140-6736(06)68615-7

Cited by 459 publications

(405 citation statements)

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“…B ronchopulmonary dysplasia (BPD) is a chronic lung disease associated with preterm babies who require mechanical ventilation and oxygen therapy for acute respiratory distress (1). BPD remains a serious and common problem in very-low-birth-weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome (RDS) ((2-4).…”

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confidence: 99%

Predictive value of soluble urokinase plasminogen activator receptor, soluble ST2, and IL-33 in bronchopulmonary dysplasia

Tunç¹,

Çekmez²,

Yıldırım

et al. 2014

Pediatr Res

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Background: Bronchopulmonary dysplasia (BPD) remains an important complication of preterm births. The soluble form of ST2 (sST2), interleukin-33 (IL-33), and soluble form of the urokinase plasminogen activator receptor (suPAR) have attracted increasing attention as biomarkers for different diseases. The aim of the current study was to assess the predictive value of plasma sST2, IL-33, and suPAR levels in patients with risk of BPD development. Methods: A total of 38 babies were studied prospectively on delivery to the neonatal intensive care unit. Serum levels of IL-33, sST2, and suPAR were measured using enzyme-linked immunosorbent assay. Serum samples were collected from umbilical cord (at the time of delivery, termed CB) and peripheral blood (on day 14, termed PB). results: Levels of suPAR (PB-suPAR) and sST2 (PB-sST2) in the peripheral blood of the BPD group were significantly higher than the corresponding levels in the non-BPD group (P < 0.001, P = 0.028, respectively. There was a statistically significant correlation between PB-suPAR levels and the severity of BPD (P < 0.001)) when the suPAR results were analyzed using the receiver operating characteristic curve. conclusion: PB-suPAR and PB-sST2 levels are sensitive and specific independent predictive biomarkers in preterm babies with BPD.B ronchopulmonary dysplasia (BPD) is a chronic lung disease associated with preterm babies who require mechanical ventilation and oxygen therapy for acute respiratory distress (1). BPD remains a serious and common problem in very-low-birth-weight infants despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome (RDS) ((2-4). The incidence of BPD is directly proportional to the degree of prematurity. BPD has a complex and multifactorial etiology, including oxygen toxicity, preterm delivery, hypoxia/ hyperoxia, infection, and inflammation (5-7). Many studies have suggested that BPD is a result of imbalance between proinflammatory and anti-inflammatory mechanisms (8,9).The ST2 gene, which produces a soluble secreted form (sST2) and a transmembrane form (ST2L) of the IL-1 receptor, is expressed in several cells, including Th2 cells, mast cells, and macrophages (10). Interleukin-33 (IL-33) was identified as a new member of the IL-1 cytokine family. It has been described as a modulator of inflammation, mediating Th2 immune responses. It has also been detected that IL-33 is involved in the pathogenesis of chronic inflammatory diseases (11). Recently, it has been shown that IL-33 can bind to ST2L and can thereby trigger Th2-associated responses. Soluble ST2, which is mainly secreted by fibroblasts, has been suggested to act as a decoy receptor by binding IL-33, thereby inhibiting signaling by ST2L (12). Elevated sST2 levels have been reported in sepsis, asthma, and acute myocardial infarction. A significant positive correlation between sST2 levels and severity of these medical conditions has been shown (13).The urokinase plasminogen activator (uPA...

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confidence: 99%

Predictive value of soluble urokinase plasminogen activator receptor, soluble ST2, and IL-33 in bronchopulmonary dysplasia

Tunç¹,

Çekmez²,

Yıldırım

et al. 2014

Pediatr Res

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“…BPD has been associated with lung injury and inflammation resulting from oxygen toxicity, barotrauma/volutrauma, and infection in the premature lung (1,2). In particular, over the past 2 decades, the level of evidence has increased regarding the existence of a link between intrauterine infection and BPD (3)(4)(5).…”

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Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants

et al. 2012

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“…Se sabe que a las 24 semanas de gestación el pulmón está en etapa canalicular del desarrollo, progresando a etapa sacular alrededor de las 30 semanas 13,15 . Por tanto, el pulmón muy inmaduro puede ser fácilmente dañado por elevadas concentraciones de oxígeno y por el trauma producido por la ventilación mecánica artificial que habitualmente es necesario para la sobrevivencia de estos niños muy inmaduros 16,18 .…”

Section: Patogénesisunclassified

“…Esto explica en parte que la denominada nueva DBP presente menor cantidad de alvéolos y de mayor tamaño, concordantes con una detención o alteración del desarrollo pulmonar normal 2,4,15,16 . Además el factor de crecimiento endotelial vascular también estaría alterado, comprometiendo la vascularización, y por ende la alveolarización del pulmón 15,16 .…”

Section: Patogénesisunclassified

“…Además el factor de crecimiento endotelial vascular también estaría alterado, comprometiendo la vascularización, y por ende la alveolarización del pulmón 15,16 . Esta disminución en el número de alvéolos y capilares pulmonares disminuye la superficie de intercambio gaseoso, siendo necesario aumentar el aporte de oxígeno adicional para mantener una oxigenación normal 19,20 .…”

Section: Patogénesisunclassified

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Actualización en Presentación y Patogénesis de la Displasia Broncopulmonar

2009

Rev. chil. pediatr.

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Update on Presentation and Pathogenesis of Brochopulmonary DysplasiaBronchopulmonary dysplasia (BPD) remains as the most frequent chronic lung disease seen among babies with very low birth weight, contributing to their morbidity and mortality. An increase in the survival of very immature babies due to improvement in pre and post natal care, has resulted in an increase in the number of newborns with BDP, although there have been no changes in the actual incidence of the disease. Objective: To describe the evolution of DBP in recent decades, the current definition, and to describe and analyze the risk factors involved in the pathogenesis of this disease. Until a few years ago, the terms BPD and chronic lung disease were used as synonyms. After the workshop sponsored by the National Institute of Health in the United States in 2001, it was recommended that the term BPD be used to describe the pulmonary sequelae of immature babies. Classic severe BPD, as described by Northway et al over forty years ago, has evolved into milder forms of chronic pulmonary damage, the so-called "new BPD", characterized by impairment of alveolarización and vascularization of the immature lung in response to multiple injuries. BPD is a multifactorial disease where major risk factors are related to pulmonary immaturity, hyperoxia, baro/volutrauma, as well as inflamation and infection. Genetic susceptibility has recently been shown to be another important risk factor. Conclusion: Bronchopulmonary Dysplasia continues to be the most frequent sequelae affecting low birth weight infants. In the past four decades, the disease has been better defined, and new pathogenetic risk factors have been established. RESUMENLa Displasia Broncopulmonar (DBP) continúa siendo la enfermedad pulmonar crónica más frecuente que afecta al recién nacido de muy bajo peso, contribuyendo a su morbilidad y mortalidad. El aumento en la sobrevida de los recién nacidos muy inmaduros, debido a la mejoría en el cuidado pre y post natal, ha aumentado el número de recién nacidos con displasia, sin cambios en su incidencia. El objetivo de esta revisión es representar los cambios en la presentación clínica de la DBP en las últimas décadas y describir ACTUALIDAD CLINICAL OVERVIEW Rev Chil Pediatr 2009; 80 (3): 213-224

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Bronchopulmonary dysplasia

Cited by 459 publications

References 122 publications

Predictive value of soluble urokinase plasminogen activator receptor, soluble ST2, and IL-33 in bronchopulmonary dysplasia

Predictive value of soluble urokinase plasminogen activator receptor, soluble ST2, and IL-33 in bronchopulmonary dysplasia

Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants

Actualización en Presentación y Patogénesis de la Displasia Broncopulmonar

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