Bronchoscopic Lung Volume Reduction for End-Stage Emphysema

Wan, Innes Y.P.; Toma, Tudor; Geddes, Duncan M.; Snell, Greg; Williams, Trevor; Venuta, Federico; Yim, Anthony P.C.

doi:10.1378/chest.129.3.518

Cited by 223 publications

(183 citation statements)

References 20 publications

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“…Controversy exists over the unilateral or bilateral surgery in one stage or multiple sessions. However, studies indicate that long-term effects of one-side LVRS are similar to that of both sides [7,8].…”

Section: Discussionmentioning

confidence: 98%

Video-Assisted Thoracoscopic Surgery for Treatment of Chronic Obstructive Pulmonary Disease

et al. 2015

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The aim of this study is to evaluate the safety and efficacy of lung volume reduction surgery (LVRS) by videoassisted thoracoscopic surgery (VATS) in the treatment of chronic obstructive pulmonary disease (COPD). A total of 90 patients with COPD from 2002 to 2012 were enrolled into our study, comprising 22 who underwent conventional thoracotomies and 68 VATS. Pulmonary function testings, arterial blood gases analysis, and quality of life between these two groups were compared. VATS was found to be superior to the conventional thoracotomy in terms of length of hospital stay, intraoperative blood loss, intubation time, volume of chest tube drainage, and postoperative pain assessment (P<0.05). However, significant differences in pulmonary function testings, arterial blood gases analysis, 6-min walking distance (6-MWD), and postoperative quality of life between the two groups were not found (P>0.05). LVRS by VATS is a safe and reliable surgical approach for the treatment of COPD, with less invasiveness and shorter hospital recovery time.

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Section: Discussionmentioning

confidence: 98%

Video-Assisted Thoracoscopic Surgery for Treatment of Chronic Obstructive Pulmonary Disease

et al. 2015

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“…A series of early studies indicated that EBV implantation substantially benefited patients in whom the target lobe collapsed and in whom target lung volume reduction (TLVR) was achieved, but TLVR was achieved in only 24.9% of patients (11)(12)(13)(14)(15). Post-procedure quality of life and exercise capacity improved to some extent for patients with no significant collapse of the target lobe, the difference was not statistically significant (16,17). Although the target lobe does not collapse, EBV implantation reduces physiological dead space and it improves the efficiency of ventilation; increased ventilation allows more air to healthy lungs and reduces dynamic hyperinflation, so patients receive a slight benefit.…”

Section: Endobronchial Valves and Intrabronchial Valvesmentioning

confidence: 97%

“…Early studies were based on observational studies and indicated that EBV implantation was safe, but most studies have found that EBV implantation has little benefit (11)(12)(13)(14)(15)(16)(17). A series of early studies indicated that EBV implantation substantially benefited patients in whom the target lobe collapsed and in whom target lung volume reduction (TLVR) was achieved, but TLVR was achieved in only 24.9% of patients (11)(12)(13)(14)(15).…”

Section: Endobronchial Valves and Intrabronchial Valvesmentioning

confidence: 99%

“…Wan et al (17) found that patients undergoing EBV implantation in one lung had more benefits than those receiving implants in both lungs. Unilateral implantation differed significantly from LVRS, which requires treatment of both lungs to have an obvious benefit.…”

Section: Endobronchial Valves and Intrabronchial Valvesmentioning

confidence: 99%

“…In some studies, ventilation/perfusion scintigraphy of the lungs is routinely performed (11)(12)(13)(14)(15)(16)(17)(18). The state of lung perfusion is usually consistent with the extent of damage (47), but in a few instances the state of lung perfusion and extent of emphysema may differ because local vascular inflammation has induced vascular remodeling, which can also lead to irregularities in pulmonary perfusion (48,49).…”

Section: Other Predictorsmentioning

confidence: 99%

See 2 more Smart Citations

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Wang

et al. 2016

BST

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Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease

Agteren

Hnin

Grosser

et al. 2017

Cochrane Database of Systematic Reviews

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Results for selected BLVR procedures indicate they can provide significant and clinically meaningful short-term (up to one year) improvements in health outcomes, but this was at the expense of increased adverse events. The currently available evidence is not sufficient to assess the effect of BLVR procedures on mortality. These findings are limited by the lack of long-term follow-up data, limited availability of cost-effectiveness data, significant heterogeneity in results, presence of skew and high CIs, and the open-label character of a number of the studies.

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Bronchoscopic Lung Volume Reduction for End-Stage Emphysema

Cited by 223 publications

References 20 publications

Video-Assisted Thoracoscopic Surgery for Treatment of Chronic Obstructive Pulmonary Disease

Video-Assisted Thoracoscopic Surgery for Treatment of Chronic Obstructive Pulmonary Disease

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Bronchoscopic lung volume reduction procedures for chronic obstructive pulmonary disease

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