Bronchoscopically Obtained Volatile Biomarkers in Lung Cancer

Darwiche, Kaid; Baumbach, J. I.; Sommerwerck, Urte; Teschler, Helmut; Freitag, Lutz

doi:10.1007/s00408-011-9324-1

Cited by 24 publications

(29 citation statements)

References 29 publications

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“…16 New biomarkers are necessary for early diagnosis of lung cancer. 17,18 The autofluorescence bronchoscope technique and biomarkers from endobronchial tissue samples are also being used for early diagnosis of the disease. 18,19 Lung cancer staging has recently been re-evaluated and a new system has been proposed.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 The autofluorescence bronchoscope technique and biomarkers from endobronchial tissue samples are also being used for early diagnosis of the disease. 18,19 Lung cancer staging has recently been re-evaluated and a new system has been proposed. [20][21][22][23][24][25] A new pathologic classification has been suggested for correct evaluation of the different molecular characteristics of the disease, along with patient survival.…”

Section: Introductionmentioning

confidence: 99%

“…44 A vessel catheter with optical coherence tomography has been constructed for accurate evaluation of structural information from developing vessels. 40 In a further study, 18 F-ZW-104, a novel positron emission tomography radioligand, was developed to display central nicotinic acetylcholine receptors in baboons, 59 and the results indicated that this new radioligand could be used in humans to study nicotinic acetylcholine receptors containing the β2 subunit. Further, in a study by Muller et al, 47 a novel optical high resolution system was developed to display adult cardiomyocytes.…”

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confidence: 99%

“…18,[33][34][35] The technique used along with the method used for pathologic evaluation of the tissue specimen determines how efficiently the disease is identified. Additional methods for enhancing diagnostic efficiency could include biomarkers or novel cell displays.…”

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confidence: 99%

“…Additional methods for enhancing diagnostic efficiency could include biomarkers or novel cell displays. 18, We have evaluated the CytoViva ® illumination nanotechnology which, apart from being a novel method of display, contains software that is able to learn and store new patterns. This method is currently being used by our department and has been shown to be efficient for identification of nonviral particles.…”

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confidence: 99%

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“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Darwiche¹,

Krauss²,

Oezkan³

et al. 2013

IJN

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Background There are currently many techniques and devices available for the diagnosis of lung cancer. However, rapid on-site diagnosis is essential for early-stage lung cancer, and in the current work we investigated a new diagnostic illumination nanotechnology. Methods Tissue samples were obtained from lymph nodes, cancerous tissue, and abnormal intrapulmonary lesions at our interventional pulmonary suites. The following diagnostic techniques were used to obtain the samples: endobronchial ultrasound bronchoscopy; flexible bronchoscopy; and rigid bronchoscopy. Flexible and rigid forceps were used because several of the patients were intubated using a rigid bronchoscope. In total, 30 tissue specimens from 30 patients were prepared. CytoViva® illumination nanotechnology was subsequently applied to each of the biopsy tissue slides. Results A spectral library was created for adenocarcinoma, epidermal growth factor receptor mutation-positive adenocarcinoma, squamous cell carcinoma, usual interstitial pneumonitis, non-specific interstitial pneumonitis, typical carcinoid tumor, sarcoidosis, idiopathic pulmonary fibrosis, small cell neuroendocrine carcinoma, thymoma, epithelioid and sarcomatoid mesothelioma, cryptogenic organizing pneumonia, malt cell lymphoma, and Wegener’s granulomatosis. Conclusion The CytoViva software, once it had created a specific spectral library for each entity, was able to identify the same disease again in subsequent paired sets of slides of the same disease. Further evaluation of this technique could make this illumination nanotechnology an efficient rapid on-site diagnostic tool.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Darwiche¹,

Krauss²,

Oezkan³

et al. 2013

IJN

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Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives

Kunze-Szikszay

Euler

Perl

2021

Appl Microbiol Biotechnol

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Diagnosis of bacterial infections until today mostly relies on conventional microbiological methods. The resulting long turnaround times can lead to delayed initiation of adequate antibiotic therapy and prolonged periods of empiric antibiotic therapy (e.g., in intensive care medicine). Therewith, they contribute to the mortality of bacterial infections and the induction of multidrug resistances. The detection of species specific volatile organic compounds (VOCs) emitted by bacteria has been proposed as a possible diagnostic approach with the potential to serve as an innovative point-of-care diagnostic tool with very short turnaround times. A range of spectrometric methods are available which allow the detection and quantification of bacterial VOCs down to a range of part per trillion. This narrative review introduces the application of spectrometric analytical methods for the purpose of detecting VOCs of bacterial origin and their clinical use for diagnosing different infectious conditions over the last decade. Key Points • Detection of VOCs enables bacterial differentiation in various medical conditions. • Spectrometric methods may function as point-of-care diagnostics in near future.

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Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects

Yamada

Otsuka

et al. 2017

Lung

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Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p < 0.001), while the VOC peaks of acetoin, isoprene, ethylbenzene, and the unknown compound were significantly higher (p < 0.001 for all) compared with the peaks of controls. Comparing VOC peaks with clinical parameters, negative correlations with VC (r =-0.393, p = 0.013), %VC (r =-0.569, p < 0.001), FVC (r = -0.440, p = 0.004), %FVC (r =-0.539, p < 0.001), DLco (r =-0.394, p = 0.018), and %DLco (r =-0.413, p = 0.008) and a positive correlation with KL-6 (r = 0.432, p = 0.005) were found for p-cymene. Conclusion We found characteristic 5 VOCs in the exhaled breath of IPF patients. Among them, the VOC peaks of p-cymene were related to the clinical parameters of IPF. These VOCs may be useful biomarkers of IPF.

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Bronchoscopically Obtained Volatile Biomarkers in Lung Cancer

Abstract: Our results indicate that VOCs in lung cancer patients are produced locally in or around the tumor, and it is most likely that these VOCs represent underlying metabolic processes of the tumor.

Cited by 24 publications

References 29 publications

“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives

Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects

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Bronchoscopically Obtained Volatile Biomarkers in Lung Cancer

Abstract: Our results indicate that VOCs in lung cancer patients are produced locally in or around the tumor, and it is most likely that these VOCs represent underlying metabolic processes of the tumor.

Cited by 24 publications

References 29 publications

&ldquo;One-stop shop&rdquo; spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

&ldquo;One-stop shop&rdquo; spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Identification of volatile compounds from bacteria by spectrometric methods in medicine diagnostic and other areas: current state and perspectives

Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects

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“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology