Bronchovascular bundle thickening on CT as a predictor of survival and brain metastasis in patients with stage IA peripheral small cell lung cancer

Sung, Pamela; Yoon, Soon Ho; Kim, Jooyoun; Hong, Jung Hee; Park, Seo-Young; Goo, Jin Mo

doi:10.1016/j.crad.2020.08.018

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Bronchovascular bundle thickening corresponds pathologically to tumor extension along the lymphatics surrounding the bronchi [46,47], and are more likely to metastasize to regional lymph nodes than adenocarcinomas with normal periphery [48,49]. Recently, this phenomenon was also found in early stage SCLC [47]. Similarly, another report indicated that patients who died from NSCLC, were significantly more tumors with bronchial signs or bronchovascular bundle thickening than those patients with a halo sign or peripheral normality [42].…”

Section: Discussionmentioning

confidence: 94%

“…Our study also showed that bronchovascular bundle thickening and pleural attachment were closely related to postoperative recurrence, suggesting that tumors involving blood vessels or pleura were more likely to lead to an increased risk of recurrence. Bronchovascular bundle thickening corresponds pathologically to tumor extension along the lymphatics surrounding the bronchi [46,47], and are more likely to metastasize to regional lymph nodes than adenocarcinomas with normal periphery [48,49]. Recently, this phenomenon was also found in early stage SCLC [47].…”

Section: Discussionmentioning

confidence: 96%

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Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma

Zhang

Zhao

et al. 2021

European Journal of Radiology

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To retrospectively investigate whether radiological and clinicopathological characteristics were associated with the presence of stage IA-IIA lung adenocarcinoma in patients at high risk for a postoperative recurrence. Materials and Methods: Three hundred twelve patients with biopsy-proven node-negative early-stage (IA-IIA) lung adenocarcinoma met the inclusion criteria for this study. Demographics data and histopathological findings were collected from medical records. Computed tomography (CT) performed approximately 1 month before surgery was manually scored using 23 CT descriptors. Univariate analyses were applied to demonstrate an association between clinicopathological and radiological features and 2-/5-year recurrences. Multivariate logistic regression was performed to assess the ability of radiological and clinicopathological features to discriminate low and high-risk factors for recurrence. A ROC curve was used to evaluate prediction performance. Results: Univariate analysis revealed that the 2-year recurrence was associated with six radiological features and two clinicopathological features, while 5-year recurrence was associated with five radiological features and two clinicopathological features. A multivariate logistic regression model of combined clinicopathological and radiological features showed that stage IIA (OR = 2.87), solid texture (solid part > 50 %: OR = 4.81; solid part = 100 %: OR = 3.61), pleural attachment (OR = 3.97) and bronchovascular bundle thickening (OR = 2.16) were associated with the independent predictors of 2-year recurrence, and stage IIA (OR = 3.52), solid texture (solid part > 50 %: OR = 3.56; solid part = 100 %: OR = 2.44) and pleural attachment (OR = 4.57) were associated with 5-year recurrence. Combined radiological and clinicopathological features could be significant indicators of 2-and 5-year recurrences (AUC = 0.784 and AUC = 0.815, respectively). Conclusions: The combination of radiological and clinicopathological features has the potential to help predict postoperative recurrence in patients with stage IA-IIA lung adenocarcinomas and guide oncologists and patients whether to undergo additional treatment after surgery.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma

Zhang

Zhao

et al. 2021

European Journal of Radiology

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“…All nodules were evaluated for the presence of air bronchograms, internal calcification, thickening of the bronchovascular bundle, and pleural tags. [ 16 ] Thickening of the bronchovascular bundle was defined as irregular thickening of peribronchovascular interstitium adjacent to the nodule [ 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical usability of 3D gradient-echo-based ultrashort echo time imaging: Is it enough to facilitate diagnostic decision in real-world practice?

Bak,

Park,

Lee

et al. 2024

PLoS ONE

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Background With recent advances in magnetic resonance imaging (MRI) technology, the practical role of lung MRI is expanding despite the inherent challenges of the thorax. The purpose of our study was to evaluate the current status of the concurrent dephasing and excitation (CODE) ultrashort echo-time sequence and the T1-weighted volumetric interpolated breath-hold examination (VIBE) sequence in the evaluation of thoracic disease by comparing it with the gold standard computed tomography (CT). Methods Twenty-four patients with lung cancer and mediastinal masses underwent both CT and MRI including T1-weighted VIBE and CODE. For CODE images, data were acquired in free breathing and end-expiratory images were reconstructed using retrospective respiratory gating. All images were evaluated through qualitative and quantitative approaches regarding various anatomical structures and lesions (nodule, mediastinal mass, emphysema, reticulation, honeycombing, bronchiectasis, pleural plaque and lymphadenopathy) inside the thorax in terms of diagnostic performance in making specific decisions. Results Depiction of the lung parenchyma, mediastinal and pleural lesion was not significant different among the three modalities (p > 0.05). Intra-tumoral and peritumoral features of lung nodules were not significant different in the CT, VIBE or CODE images (p > 0.05). However, VIBE and CODE had significantly lower image quality and poorer depiction of airway, great vessels, and emphysema compared to CT (p < 0.05). Image quality of central airways and depiction of bronchi were significantly better in CODE than in VIBE (p < 0.001 and p = 0.005). In contrast, the depiction of the vasculature was better for VIBE than CODE images (p = 0.003). The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were significant greater in VIBE than CODE except for SNRlung and SNRnodule (p < 0.05). Conclusions Our study showed the potential of CODE and VIBE sequences in the evaluation of localized thoracic abnormalities including solid pulmonary nodules.

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Spectral CT based radiomics for predicting brain metastases in patients with lung cancer

Cao,

Shu

2024

Int J Radiat Res

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Bronchovascular bundle thickening on CT as a predictor of survival and brain metastasis in patients with stage IA peripheral small cell lung cancer

Cited by 3 publications

References 18 publications

Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma

Association of postoperative recurrence with radiological and clinicopathological features in patients with stage IA–IIA lung adenocarcinoma

Clinical usability of 3D gradient-echo-based ultrashort echo time imaging: Is it enough to facilitate diagnostic decision in real-world practice?

Spectral CT based radiomics for predicting brain metastases in patients with lung cancer

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