Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat

Ye, Rongcai; Yan, Chunlong; Zhou, Huiqiao; Huang, Yuanyuan; Dong, Meng; Zhang, Hanlin; Jiang, Xiaoxiao; Yuan, Shouli; Chen, Li; Jiang, Rui; Cheng, Zhen; Zheng, Kexin; Zhang, Chenglong; Jin, Wanzhu

doi:10.3389/fendo.2021.744628

Cited by 15 publications

(10 citation statements)

References 41 publications

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“…BAT activity tends to decrease in patients with PCOS owing to high central adiposity and obesity [ 77 ]. A recent report indicated that cold exposure was beneficial for the treatment of PCOS as it reduced the levels of circulating testosterone and luteinizing hormone (LH), the expression of steroidogenic enzymes, inflammatory factors, and cystic ovarian follicles in rats with PCOS [ 78 ]. Additionally, BAT transplantation ameliorated PCOS phenotypes by improving insulin resistance and infertility in mice and rats [ 79 , 80 ].…”

Section: Physiological Role Of Brown Fatsmentioning

confidence: 99%

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

Takeda

Harada

Yoshikawa

et al. 2023

IJMS

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Brown fats specialize in thermogenesis by increasing the utilization of circulating blood glucose and fatty acids. Emerging evidence suggests that brown adipose tissue (BAT) prevents the incidence of obesity-associated metabolic diseases and several types of cancers in humans. Mitochondrial energy metabolism in brown/beige adipocytes regulates both uncoupling protein 1 (UCP1)-dependent and -independent thermogenesis for cold adaptation and the utilization of excess nutrients and energy. Many studies on the quantification of human BAT indicate that mass and activity are inversely correlated with the body mass index (BMI) and visceral adiposity. Repression is caused by obesity-associated positive and negative factors that control adipocyte browning, de novo adipogenesis, mitochondrial energy metabolism, UCP1 expression and activity, and noradrenergic response. Systemic and local factors whose levels vary between lean and obese conditions include growth factors, inflammatory cytokines, neurotransmitters, and metal ions such as selenium and iron. Modulation of obesity-associated repression in human brown fats is a promising strategy to counteract obesity and related metabolic diseases through the activation of thermogenic capacity. In this review, we highlight recent advances in mitochondrial metabolism, thermogenic regulation of brown fats, and human metabolic diseases.

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Section: Physiological Role Of Brown Fatsmentioning

confidence: 99%

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

Takeda

Harada

Yoshikawa

et al. 2023

IJMS

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“…Given that the TGF-β–MST1 axis is known to suppress the development of BAT, the inhibition of this axis by follistatin was demonstrated to lead to WAT browning, mitochondrial biogenesis and thereby the activation of BAT thermogenesis [ 193 ]. The activation of BAT in rats with PCOS by cold exposure reduced the circulating levels of testosterone and LH and decreased ovarian expression of steroidogenic enzymes, leading to improved ovulation and fertility [ 194 ]. Thus, follistatin has been suggested to have therapeutic potential for the treatment of metabolic disorders and PCOS through the increase in BAT mass and activity [ 193 ].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

“…In rat PCOS models, the whitening of BAT can be observed. In this model, BAT whitening could be reversed by the cold exposure of rats with PCOS (4 °C for 20 days), and the batokines secreted by the reactivated BAT normalized the estrous cycle, decreased the serum levels of testosterone, LH and inflammatory factors and led to improved ovulation [ 194 ]. Notably, transplantation of BAT was reported to reverse polycystic ovaries, and improve infertility and IR in rodents with PCOS [ 111 ].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Schüler-Toprak¹,

Ortmann²,

Buechler³

et al. 2022

Biomedicines

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Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.

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“…However, the health benefits of cold exposure were inconsistent in patients and animals ( 85 , 86 ). A recent study showed that cold exposure to 4°C for 20 days reversed the acyclicity of the oestrous cycle and reduced the circulating levels of testosterone and luteinizing hormone (LH) by activating endogenous BAT in rats with PCOS ( 87 ). Furthermore, the expression of steroidogenic enzymes and inflammatory factors was significantly reduced in the ovaries of rats with PCOS.…”

Section: Bat As a Novel Management Strategy For Polycystic Ovary Synd...mentioning

confidence: 99%

“…Furthermore, the expression of steroidogenic enzymes and inflammatory factors was significantly reduced in the ovaries of rats with PCOS. Histological analysis showed that cold exposure significantly improved ovulation and fertility with a reduction in cystic ovarian follicles and an increase in the corpus luteum in rats with PCOS ( 87 ). These findings indicate that cold exposure may be a novel strategy for the treatment of PCOS.…”

Section: Bat As a Novel Management Strategy For Polycystic Ovary Synd...mentioning

confidence: 99%

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

Zhang

et al. 2022

Front. Endocrinol.

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Brown adipose tissue (BAT), a unique tissue, plays a key role in metabolism and energy expenditure through adaptive nonshivering thermogenesis. It has recently become a therapeutic target in the treatment of obesity and metabolic diseases. The thermogenic effect of BAT occurs through uncoupling protein-1 by uncoupling adenosine triphosphate (ATP) synthesis from energy substrate oxidation. The review discusses the recent developments and progress associated with the biology, function, and activation of BAT, with a focus on its therapeutic potential for the treatment of polycystic ovary syndrome (PCOS). The endocrine activity of brown adipocytes affects the energy balance and homeostasis of glucose and lipids, thereby affecting the association of BAT activity and the metabolic profile. PCOS is a complex reproductive and metabolic disorder of reproductive-age women. Functional abnormalities of adipose tissue (AT) have been reported in patients with PCOS. Numerous studies have shown that BAT could regulate the features of PCOS and that increases in BAT mass or activity were effective in the treatment of PCOS through approaches including cold stimulation, BAT transplantation and compound activation in various animal models. Therefore, BAT may be used as a novel management strategy for the patients with PCOS to improve women’s health clinically. It is highly important to identify key brown adipokines for the discovery and development of novel candidates to establish an efficacious therapeutic strategy for patients with PCOS in the future.

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Brown Adipose Tissue Activation by Cold Treatment Ameliorates Polycystic Ovary Syndrome in Rat

Cited by 15 publications

References 41 publications

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

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