BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency

Zhang, Cong; Lin, Huaisong; Zhang, Yanqi; Xing, Qi; Zhang, Jingyuan; Zhang, Di; Liu, Yancai; Chen, Qianyu; Zhou, Tiancheng; Wang, Junwei; Shan, Yongli; Pan, Guoshun

doi:10.1016/j.isci.2023.105939

Cited by 9 publications

(6 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The heatmap was ordered by HBO1_F peak from highest to lowest. H3K4me3 ( 23 ) and H3K27me3 ( 24 ) ChIP-seq data were published. ( H ) Overlap between HBO1_F targeted and H3K14ac, H3K4me3, and H3K27me3 respectively targeted genes in hESCs.…”

Section: Resultsmentioning

confidence: 99%

HBO1 determines SMAD action in pluripotency and mesendoderm specification

Zhang,

Shan,

Lin

et al. 2024

Nucleic Acids Research

Self Cite

View full text Add to dashboard Cite

TGF-β signaling family plays an essential role to regulate fate decisions in pluripotency and lineage specification. How the action of TGF-β family signaling is intrinsically executed remains not fully elucidated. Here, we show that HBO1, a MYST histone acetyltransferase (HAT) is an essential cell intrinsic determinant for TGF-β signaling in human embryonic stem cells (hESCs). HBO1−/− hESCs fail to response to TGF-β signaling to maintain pluripotency and spontaneously differentiate into neuroectoderm. Moreover, HBO1 deficient hESCs show complete defect in mesendoderm specification in BMP4-triggered gastruloids or teratomas. Molecularly, HBO1 interacts with SMAD4 and co-binds the open chromatin labeled by H3K14ac and H3K4me3 in undifferentiated hESCs. Upon differentiation, HBO1/SMAD4 co-bind and maintain the mesoderm genes in BMP4-triggered mesoderm cells while lose chromatin occupancy in neural cells induced by dual-SMAD inhibition. Our data reveal an essential role of HBO1, a chromatin factor to determine the action of SMAD in both human pluripotency and mesendoderm specification.

show abstract

Section: Resultsmentioning

confidence: 99%

HBO1 determines SMAD action in pluripotency and mesendoderm specification

Zhang,

Shan,

Lin

et al. 2024

Nucleic Acids Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…These thinned 2D material-based devices could potentially be given the topmost attention in the coming time from the research community. [230][231][232][233][234][235][236][237] To visualize the development roadmap of this research direction, the top-down layer-by-layer thinning strategies were expressed as a knight that is atomically slicing the topmost thinned layer of 2D materials, which can be applied to artificially grown multilayer materials to date (Fig. 21).…”

Section: Conclusion and Outlooksmentioning

confidence: 99%

Layer-by-layer thinning of two-dimensional materials

Pham,

Mai,

et al. 2024

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…Power density [W kg −1 ] Experimental excitation Rome et al [58] 0.13 5.6 km h −1 Shepertycky et al [ 42] 0.23 Walking Gao et al [ 38] 0.02 0.75 Hz Zhang et al [59] 0.07 4 Hz…”

Section: Referencesmentioning

confidence: 99%

A Self‐Sensing and Self‐Powered Wearable System Based on Multi‐Source Human Motion Energy Harvesting

Hao,

Gong,

et al. 2024

Small

View full text Add to dashboard Cite

Wearable devices play an indispensable role in modern life, and the human body contains multiple wasted energies available for wearable devices. This study proposes a self‐sensing and self‐powered wearable system (SS‐WS) based on scavenging waist motion energy and knee negative energy. The proposed SS‐WS consists of a three‐degree‐of‐freedom triboelectric nanogenerator (TDF‐TENG) and a negative energy harvester (NEH). The TDF‐TENG is driven by waist motion energy and the generated triboelectric signals are processed by deep learning for recognizing the human motion. The triboelectric signals generated by TDF‐TENG can accurately recognize the motion state after processing based on Gate Recurrent Unit deep learning model. With double frequency up‐conversion, the NEH recovers knee negative energy generation for powering wearable devices. A model wearing the single energy harvester can generate the power of 27.01 mW when the movement speed is 8 km h−1, and the power density of NEH reaches 0.3 W kg−1 at an external excitation condition of 3 Hz. Experiments and analysis prove that the proposed SS‐WS can realize self‐sensing and effectively power wearable devices.

show abstract

BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency

Cited by 9 publications

References 74 publications

HBO1 determines SMAD action in pluripotency and mesendoderm specification

HBO1 determines SMAD action in pluripotency and mesendoderm specification

Layer-by-layer thinning of two-dimensional materials

A Self‐Sensing and Self‐Powered Wearable System Based on Multi‐Source Human Motion Energy Harvesting

Contact Info

Product

Resources

About