2009
DOI: 10.3349/ymj.2009.50.1.142
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Brucella Endocarditis with Splenic Abscess: A Report of the First Case Diagnosed in Korea

Abstract: Human brucellosis has a broad spectrum of clinical manifestations, which includes endocarditis, a focal complication that is uncommon yet responsible for the majority of associated deaths. The most successful treatment outcomes of Brucella endocarditis have been reported with usage of both antimicrobial agents and surgery. However, there are few reports on the treatment of Brucella endocarditis using antibiotics only. We report the first case in Korea of Brucella endocarditis with aortic valve vegetations and … Show more

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Cited by 10 publications
(10 citation statements)
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“…Underlying medical conditions, possibly explaining the development of focal abscesses due to immune suppression or shedding from endocardial infection, were reported rarely: three patients had hematologic disorders (thalassemia, 6 monoclonal gammopathy, 7 sickle-cell anemia [own]); three patients suffered from cardiac diseases (two endocarditis, 8,9 one rheumatic aortic valve replacement 10 ); two patients were pregnant at the time of diagnosis 11,12 ; two patients suffered from diabetes 13,14 ; one patient had hepatitis 15 and one patient allergic rhinitis. 16 Other patients were described as having no underlying disease or no condition was specified.…”
Section: Resultsmentioning
confidence: 99%
“…Underlying medical conditions, possibly explaining the development of focal abscesses due to immune suppression or shedding from endocardial infection, were reported rarely: three patients had hematologic disorders (thalassemia, 6 monoclonal gammopathy, 7 sickle-cell anemia [own]); three patients suffered from cardiac diseases (two endocarditis, 8,9 one rheumatic aortic valve replacement 10 ); two patients were pregnant at the time of diagnosis 11,12 ; two patients suffered from diabetes 13,14 ; one patient had hepatitis 15 and one patient allergic rhinitis. 16 Other patients were described as having no underlying disease or no condition was specified.…”
Section: Resultsmentioning
confidence: 99%
“…Brusella endokarditinde literatürde en sık aortik kapak tutulumu olduğu görülmektedir ve %82'ye varan oranda aortik kapak tutulumu gösterilmiştir ve bizim çalışmamızda bu oran %62,5'tir (19,20). Brusella endokarditinde aortik kapak tutulumu çok sayıda sistemik embolik komplikasyona yol açmaktadır: Süperiyor mezenterik arter anevrizması, miyokardit, splenik apse ve subklavyan arter trombozu gibi pek çok komplikasyon bildirilmiştir (21)(22)(23)(24). Takip ettiğimiz tüm hastalar kapakta vejetasyon ile gelmiş olup, sadece bir hastada periannüler aortik apse de mevcuttu.…”
Section: Discussionunclassified
“…Brusellozun neden olduğu dalak apsesi nadir olup literatürde olgu sunumları şeklinde bulunmaktadır (3-13). Birkaç olguda bruselloza bağlı infektif endokarditin bir komplikasyonu olarak dalak apsesi geliştiği görülmüştür (4,6,11). Olgumuza da ekokardiyografi yapılmış ve infektif endokardit saptanmamıştır.…”
Section: İrdelemeunclassified
“…Tedavi süresiyle ilgili olarak kesin bir görüş birliği olmamakla birlikte bu süre altı haftadan az olmamalıdır. Bildirilen birçok vakada farklı tedavi sürelerinin uygulandığı görülmüştür (4)(5)(6)(8)(9)(10)13,14). Sayılır ve arkadaşları (5) vakalarına ko-trimoksazol, doksisiklin ve rifampisin başlamışlar, radyolojik olarak dalak apsesi kaybolana kadar 7 ay boyunca tedaviyi sürdürdüklerini bildirmişlerdir.…”
Section: İrdelemeunclassified