Brucella Optic Neuritis

Abducens nerve palsy and optic neuritis as initial manifestation in brucellosis

“…Another theory is a vasculitic process. The bacterial antigen, antibody, and complement complex are deposited in the vasa nervosum with vascular and perivascular infiltrates [6,14]. Our patient's CSF pressure was normal but at the higher part of the normal range, and he had used 10 days' prednisolone before admission to our hospital.…”

“…The most frequently involved nerve is the acoustic nerve [5,10]. There have been a few reports about isolated optic neuritis or isolated abducens palsy [3,6,11].…”

“…Treatment of cranial nerve involvement in brucellosis consists of antibiotic therapy and corticosteroids [5,6]. Doxycycline in combination with 2 or more other drugs (e.g.…”

“…However, some severe complications such as meningitis, meningoencephalitis, myelitis, radiculoneuritis, ruptured mycotic aneurysm, myositis, brain abscess, and meningovascular syndromes may occur in 2 Á10% of patients with brucellosis [3 Á5]. Papillitis, papilloedema, retrobulbar neuritis, optic atrophy, and ophthalmoplegia due to lesions in the cranial, oculomotor, trochlear, and abducens nerves may occur in Brucella meningoencephalitis [6]. Patients may present with neurological disorders but without systemic signs and symptoms [5].…”

Neurobrucellosis as an Exceptional Cause of Transient Ischemic Attacks

“…Uncommon clinical presentations of NB such as migraine, parkinsonism, optic neuritis, chronic intracranial hypertension, and epilepsy were described (8,(10)(11)(12)(13)(14)(15). Brucellar meningitis may also behave as an exclusively neurologic disease, mimicking vascular accidents or neurological diseases that are frequently paroxysmal and recurrent (16).…”