Brucellosis and proteomics: an approach in Albania

Mavromati, Jani

doi:10.3920/978-90-8686-751-6_18

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…In early studies, the complete proteomic profile of B. melitensis was described [ 108 ]; this could be used as a reference to evaluate the virulence of strains of the organism. Later work involved the use of LC-MS (liquid chromatography-mass spectrometry) for the establishment of differences in the protein profile in the blood serum of sheep infected or not with B. melitensis ; the aim was to distinguish naturally infected animals from vaccinated ones and thus to monitor the progress of vaccination campaigns and the national strategies to control the infection [ 109 ]. In this study, the numbers of peroxisome protein partners were found to be overexpressed only in the group of vaccinated animals.…”

Section: Proteomics Applications In Zoonotic Infectionsmentioning

confidence: 99%

Applied Proteomics in ‘One Health’

Katsarou

Billinis

Galamatis³

et al. 2021

Proteomes

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‘One Health’ summarises the idea that human health and animal health are interdependent and bound to the health of ecosystems. The purpose of proteomics methodologies and studies is to determine proteins present in samples of interest and to quantify changes in protein expression during pathological conditions. The objectives of this paper are to review the application of proteomics technologies within the One Health concept and to appraise their role in the elucidation of diseases and situations relevant to One Health. The paper develops in three sections. Proteomics Applications in Zoonotic Infections part discusses proteomics applications in zoonotic infections and explores the use of proteomics for studying pathogenetic pathways, transmission dynamics, diagnostic biomarkers and novel vaccines in prion, viral, bacterial, protozoan and metazoan zoonotic infections. Proteomics Applications in Antibiotic Resistance part discusses proteomics applications in mechanisms of resistance development and discovery of novel treatments for antibiotic resistance. Proteomics Applications in Food Safety part discusses the detection of allergens, exposure of adulteration, identification of pathogens and toxins, study of product traits and characterisation of proteins in food safety. Sensitive analysis of proteins, including low-abundant ones in complex biological samples, will be achieved in the future, thus enabling implementation of targeted proteomics in clinical settings, shedding light on biomarker research and promoting the One Health concept.

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Section: Proteomics Applications In Zoonotic Infectionsmentioning

confidence: 99%

Applied Proteomics in ‘One Health’

Katsarou

Billinis

Galamatis³

et al. 2021

Proteomes

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“…Eschenbrenner et al (2002Eschenbrenner et al ( , 2006 used 2-D PAGE and peptide mass fingerprinting and described the proteome of the Rev 1 vaccinal strain and the 16 M pathogenic strain; they identified that expression of an immunogenic bacterial outer membrane protein, of proteins utilised in iron acquisition and of proteins playing a role in sugar binding, lipid degradation and amino acid binding was modified in Rev 1. Finally, Mavromati (2012) used proteomics methodologies (LC MS) and established differences in various blood serum proteins between sheep infected or not with B. melitensis, with the aim to monitor progress of vaccination for controlling the infection.…”

Section: Mastitismentioning

confidence: 99%

Use of proteomics in the study of microbial diseases of small ruminants

Katsafadou

Tsangaris

Billinis

et al. 2015

Veterinary Microbiology

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“…Modern proteomics and bioinformatics technologies can be employed to fully characterise and map milk proteomes or, otherwise, to provide details regarding differentially expressed proteins in milk. In any case, it is appropriate to mention that successful proteomics investigations depend upon availability of complete databases, which would include gene and protein sequence information for the animal species of interest [6,25].…”

Section: Use Of Proteomics In the Study Of Milk Production In Healmentioning

confidence: 99%

Use of Proteomics in the Study of Mastitis in Ewes

2019

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The objective of this review is to describe the usage and applicability of proteomics technologies in the study of mastitis in ewes. In ewes, proteomics technologies have been employed for furthering knowledge in mastitis caused by various agents (Staphylococcus aureus, Staphylococcus chromogenes, Mannheimia haemolytica, Streptococcus uberis, Mycoplasma agalactiae). Studies have focused on improving knowledge regarding pathogenesis of the infections and identifying biomarkers for its diagnosis. Findings have revealed that ewes with mastitis mount a defence response, controlled by many proteins and over various mechanisms and pathways, which are interdependent at various points. Many proteins can participate in this process. Moreover, as the result of proteomics studies, cathelicidins and serum amyloid A have been identified as proteins that can be used as biomarkers for improved diagnosis of the disease. In the long term, proteomics will contribute to improvements in the elucidation of the pathogenesis of mastitis. Further in-depth investigations into the various proteomes and application of new methodological strategies in experimental and clinical studies will provide information about mastitis processes, which will be of benefit in controlling the disease. Improvement of diagnostic techniques, establishment of prognostic tools and development of vaccines are key areas for targeted research.

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Brucellosis and proteomics: an approach in Albania

Cited by 4 publications

References 4 publications

Applied Proteomics in ‘One Health’

Applied Proteomics in ‘One Health’

Use of proteomics in the study of microbial diseases of small ruminants

Use of Proteomics in the Study of Mastitis in Ewes

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