Bryophyllum pinnatum inhibits arginase II activity and prevents oxidative damage occasioned by carbon tetrachloride (CCl4) in rats

Effect of dietary inclusion of pumpkin (Cucurbita pepo L) seed on nephrotoxicity occasioned by cisplatin in experimental rats

“…This result revealed that dietary intervention with roasted pumpkin seed diet may trigger the availability of arginine which is needed for NO production. Hence, availability of arginine regulates the NO/cGMP pathway (Anadozie et al, 2018;Reddy et al, 2015). This results corroborates with the reports of some researchers who reported that food constituent and plant prod- The histopathological changes seen in the renal tissues of cisplatin-induced nephrotoxic untreated group further affirms renal injury which might be activated by oxidative damage.…”

“…In conditions related with renal injury/harm, arginase has been reported to be an important biomarker (Anadozie, Akinyemi, Agunbiade, Ajiboye, & Adewale, 2018; You, Gao, Cooper, Morris, & Awad, 2013). The significant role of arginase in protecting renal tissue and reduced enzymatic activity has been connected with lessening of albuminuria, oxidative stress, plasma creatinine levels and kidney macrophage enlistment (You et al., 2013).…”

“…Our results uncovered high levels of arginase activity in the renal tissue of cisplatin‐induced nephrotoxic untreated group. The rapid degradation of arginine by arginase reduces its availability in the renal tissues as a substrate for nitric oxide synthase, which uses the same substrate for the production of nitric oxide (Anadozie et al., 2018). This outcome likewise relates with low levels of NO noticed after treatment with cisplatin in the renal tissue of cisplatin‐induced nephrotoxic untreated group.…”

“…This result revealed that dietary intervention with roasted pumpkin seed diet may trigger the availability of arginine which is needed for NO production. Hence, availability of arginine regulates the NO/cGMP pathway (Anadozie et al., 2018; Reddy et al., 2015). This results corroborates with the reports of some researchers who reported that food constituent and plant product inhibit arginase activities in some toxic chemicals or xenobiotics‐induced kidney damage (Akinyemi et al., 2017; Akomolafe, Olasehinde, Adewale, & Ajayi, 2019; Anadozie et al., 2018).…”

Antimicrobial and Antiproliferative Activities of Vincetoxicum canescens subsp. canescens and Vincetoxicum cancescens subsp. pedunculata Seeds

“…4 Günümüzde birçok farmakolojik etki, düşük maliyet, elde edilebilirlik gibi özelliklere ek olarak yüksek etki ve düşük yan etki bitki ve bitkilerden elde edilen ürünlerin önemini daha da arttırmaktadır. 5 Vincetoxicum N.M. Wolf cinsi (Apocynaceae: subfamilya Asclepiadoideae) yaklaşık 100 türü bulunan Kuzey Amerika 6 , Avrupa, Asya ve Japonya'da 7 yayılış gösteren bir cinstir. Vincetoxicum cinsine ait türlerin kökleri, yaprakları ve kuru tohumları tıbbi özellikleri nedeniyle uzun zamandır geleneksel tıpta kullanılmaktadır.…”