BSA-modified gold nanoclusters for sensing of folic acid

Hemmateenejad, Bahram; Shakerizadeh-Shirazi, Fatemeh; Samari, Fayezeh

doi:10.1016/j.snb.2014.03.075

Cited by 100 publications

(44 citation statements)

References 37 publications

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“…Specically, although BSA stabilized AuNCs (AuNCs@BSA) with red emission have been also used as a probe to determine FA and some conditions of experiments reported are even similar to us, such dual-emission phenomenon has not been noticed and mentioned in these reports. 22,23 As for FTIR spectrum (Fig. 1d), ve characteristic peaks of AuNCs@MUA were observed at 3400 cm À1 (O-H), 2920…”

Section: Synthesis and Characterization Of Auncs@muamentioning

confidence: 83%

“…22,23 Besides, Kamla Rawat et al found that ZnSe and ZnSe@ZnS QDs could determine FA via uorescence enhancement. 24 Nonetheless, these reported probes are totally based on one-single uorescence response, which are easily interfered by many factors, such as instrumental parameters, microenvironment impact, concentration of sensors and photobleaching, etc.…”

Section: Introductionmentioning

confidence: 99%

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11-Mercaptoundecanoic acid capped gold nanoclusters as a fluorescent probe for specific detection of folic acid via a ratiometric fluorescence strategy

et al. 2018

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A novel ratiometric fluorescence strategy is developed for specific detection of folic acid (FA) by using 11-mercaptoundecanoic acid protected gold nanoclusters (AuNCs@MUA). In this design, the fluorescence color of the probe can be switched among red, pink, violet and blue by varying the concentration of FA.AuNCs@MUA possesses strong fluorescence peaking at 612 nm (R-signal) and FA exhibits blue emissive auto-fluorescence at 446 nm (B-signal), showing a large emission shift of $170 nm. When AuNCs@MUA approaches FA through electrostatic binding, the R-signal decreases while the B-signal increases with titration of FA. Based on the above phenomenon, a radiometric analysis platform is constructed for FA target detection, with a wide linear response range from 0 to 20 mM, and an excellent detection limit of 26 nM. This new ratiometric strategy exhibits low background, and wide signal changes in a low concentration range, which presents obvious advantages over most previous FA detections based on single-responsive fluorescence methods. Furthermore, the proposed method is successfully applied to determine FA in human serum samples.

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Section: Synthesis and Characterization Of Auncs@muamentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

11-Mercaptoundecanoic acid capped gold nanoclusters as a fluorescent probe for specific detection of folic acid via a ratiometric fluorescence strategy

et al. 2018

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“…Moreover, other important small biomolecules, such as ATP [79,92], bilirubin [93], cholesterol [94], FA [95], heparin [96], histidine [97], methotrexate [98], urea [99], and uric acid [100], can also be detected by using fluorescent AuNCs.…”

Section: Detection Of Small Biomoleculesmentioning

confidence: 99%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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“…Colorimetric methods such as chemiluminescence, fluorescence analysis, and spectrophotometry have been applied for FA analysis (Emara, Masujima, Zarad, Kamal, & ElBagary, 2012;Lima, Vieira, Fernandes, Tanakaa, & Reis, 2016;Nagaraja, Vasantha, & Yathirajan, 2002), but these methods are not suitable for complex food matrices. To improve detection sensitivity, biosensors have been developed based on electrochemistry (Raoof, Teymoori, Khalilzadeh, & Ojani, 2015) and spectroscopy (Hemmateenejad, Shakerizadeh-shirazi, & Samari, 2014;Yang, Tan, Shih, & Cheng, 2014;Zhang, Wang, Qu, Luo, & Li, 2014). However, the use of these biosensors has been limited due to complex sample preparation steps and expensive equipment.…”

Section: Introductionmentioning

confidence: 99%

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

Kong

Liu

Song

et al. 2016

Food and Agricultural Immunology

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Folic acid (FA) is an important vitamin for human growth and development, especially for pregnant women. A sensitive, rapid, and accurate FA detection method is required to assess the nutritional quality and safety of foods. A monoclonal antibody against FA was prepared for the development of indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and lateral-flow immunochromatographic assay (ICA) strip. The 50% inhibitory concentration and limit of detection of ic-ELISA were 0.12 and 0.018 ng/ml, respectively. The visual limit of detection and cut-off values of the lateral-flow ICA strip were 0.5 and 2.5 ng/ ml, respectively. Using the ICA strip, FA recovery rates were 89-98% from energy drinks and 73-87% for milk samples and were in good agreement with those obtained from the conventional microbiological assay method. Our developed methods are sensitive, convenient, effective, and suitable for on-site detection and rapid mass screening of food samples. ARTICLE HISTORY

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BSA-modified gold nanoclusters for sensing of folic acid

Cited by 100 publications

References 37 publications

11-Mercaptoundecanoic acid capped gold nanoclusters as a fluorescent probe for specific detection of folic acid via a ratiometric fluorescence strategy

11-Mercaptoundecanoic acid capped gold nanoclusters as a fluorescent probe for specific detection of folic acid via a ratiometric fluorescence strategy

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Development of ic-ELISA and lateral-flow immunochromatographic assay strip for the detection of folic acid in energy drinks and milk samples

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