BT-11 is effective for enhancing cognitive functions in the elderly humans

Shin, Ki Young; Lee, Jun-Young; Won, Beom Young; Jung, Hee Yeon; Koppula, Sushruta; Suh, Yoo‐Hun

doi:10.1016/j.neulet.2009.08.033

Cited by 50 publications

(32 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRP has been reported to possess sedative activity [8]. RP shows repairing effects on the memory and behavioral deficits in rats [9], exhibits neuroprotective effects [10], [11], enhances cognition and memory in elderly adults [12], [13]. This study was to assess the efficacy of SS against AD.…”

Section: Introductionmentioning

confidence: 99%

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Wang

Zhao

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Wang

Zhao

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Modern pharmacological studies have already demonstrated that Polygalae Radix extract exhibits a wide variety of effects, such as hypotensive [7] , anti-inflammatory [8] , anti-depressive [9] , anti-oxidative and antiapoptotic [10] effects, cognitive improvements and cerebral protection [11] . The Polygalae Radix extract BT-11 has been shown to have memory-enhancing effects in rats with scopolamineinduced amnesia [12] and cognition-improving effects in two randomized, double-blind, placebo-controlled comparison studies, one in healthy adults and one in elderly humans [13,14] . However, the biologically active components of Polygalae Radix extract remains unclear, and additional preclinical studies are necessary to develop more effective monomers from Polygalae Radix extracts.…”

Section: Introductionmentioning

confidence: 99%

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

et al. 2016

View full text Add to dashboard Cite

Aim: Recent studies show that the extract of a Chinese herb Polygalae Radix exerts cognition-enhancing actions in rats and humans. The aim of this study was to characterize the pharmacological profiles of active compounds extracted from Polygalae Radix. Methods: Two fractions P3 and P6 and two compounds PTM-15 and polygalasaponin XXXII (PGS32) were prepared. Neuroprotective effects were evaluated in primary cortical neurons exposed to high concentration glutamate, serum deficiency or H 2 O 2 . Anti-dementia actions were assessed in scopolamine-induced amnesia in mice using step-through avoidance tests and channel water maze tests. After conducting the channel water maze tests, TrkB phosphorylation in mouse hippocampus was detected using Western blotting. Long-term potentiation (LTP) was induced in the dentate gyrus in adult rats; PGS32 (5 μL 400 μmol/L) was injected into the lateral cerebral ventricle 20 min after high frequency stimulation (HFS). Results: Compared to the fraction P6, the fraction P3 showed more prominent neuroprotective effects in vitro and cognitionenhancing effects in scopolamine-induced amnesia in mice. One active compound PGS32 in the fraction P3 exerted potent cognitionenhancing action: oral administration of PGS32 (0.125 mg· kg -1 ·d -1 ) for 19 days abolished scopolamine-induced memory impairment in mice. Furthermore, PGS32 (0.5 and 2 mg· kg -1 ·d -1 ) significantly stimulated the phosphorylation of TrkB in the hippocampus. Intracerebroventricular injection of PGS32 significantly enhanced HFS-induced LTP in the dentate gyrus of rats. Conclusion: PGS32 attenuates scopolamine-induced cognitive impairments in mice, suggesting that it has a potential for the treatment of cognitive dysfunction and dementia.

show abstract

“…Spatial cognition in an eight-arm radial maze was also noted to be improved in mice after Polygala tenuifolia treatment [31]. In elderly human, Polygala tenuifolia was used as a prophylactic and the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD) and Mini-Mental State Examination (MMSE) tests were used in this cohort and illustrated an improvement after Polygala tenuifolia administration [32]. It is also interesting that this drug in the experimental animals did not only act on the cerebral cortex or specifically the hippocampus, but also majorly activated the basal forebrain which sent diffuse projections onto the cortex [33].…”

Section: Polygala Tenuifoliamentioning

confidence: 99%

Comparison of Two Old Phytochemicals versus Two Newly Researched Plant‐Derived Compounds: Potential for Brain and Other Relevant Ailments

Wang

Liang

Yew

2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Among hundreds of formulae of Chinese herbal prescriptions and recently extracted active components from the herbs, some of which had demonstrated their functions on nervous system. For the last decade or more, Gingko biloba and Polygala tenuifolia were widely studied for their beneficial effects against damage to the brain. Two compounds extracted from Apium graveolens and Rhizoma coptidis, butylphthalide and berberine, respectively, received much attention recently as potential neuroprotective agents. In this review, the two traditionally used herbs and the two relatively new compounds will be discussed with regard to their potential advantages in alleviating brain and other relevant ailments.

show abstract

BT-11 is effective for enhancing cognitive functions in the elderly humans

Cited by 50 publications

References 16 publications

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

Comparison of Two Old Phytochemicals versus Two Newly Researched Plant‐Derived Compounds: Potential for Brain and Other Relevant Ailments

Contact Info

Product

Resources

About