BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival

Abstract

Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC.

Gene Expression Profiling of Intrahepatic Cholangiocarcinoma

“…Using unsupervised hierarchical clustering analysis, with fold change cut-off >20, 42 genes were up-regulated in tumor tissues and 204 down-regulated with only 3 up-regulated genes (BUB1B, HOXB7 and TOP2A) in agreement with the previous report (Hansel et al, 2003;Obama et al, 2005;Jinawath et al, 2006). BUB1B [budding uninhibited by benzimidazones 1 homolog beta (yeast)] encodes a kinase involved in spindle checkpoint function and plays a role in the inhibition of anaphase-promoting complex/cyclosome, delaying the onset of anaphase and ensuring proper chromosome segregation (Davenport et al, 1999), over expression of BUB1B is significantly correlation with a less advanced pathologic stage in oral squamous cell carcinoma (Rizzardi et al, 2011). HOXB7 (homeobox protein Hox-B7) is a member of the Antp homeobox family, which functions as a sequence-specific transcription factor involved in cell proliferation and differentiation (McAlpine and Shows, 1990), over expression of HOXB7 is significantly correlate with advance stage and poor prognosis of colorectal cancer (Liao et al, 2011) and oral squamous cell carcinoma (Bitu et al, 2012), TOP2A (DNA topoisomerase II-alpha) encodes an enzyme that controls and alters the topologic state of DNA during transcription (Watt and Hickson, 1994), over expression of TOP2A is associated with better overall survival and disease-free survival in early breast cancer treated with anthracyclines (Arriola et al, 2007).…”

Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation

“…All three of these kinases have recently been shown to have a role in other malignancies and are interesting candidates for genes in the context of the malignant transformation of plexiform neurofibromas: BUB1B and BUB1 are part of the spindle assembly checkpoint that ensures proper segregation of the chromosomes. [36][37][38][39] Alterations in BUB1B have been documented in a number of cancers including breast cancer, lung cancer, colon cancer and gastric cancer. 37,38,[40][41][42][43][44] In these, BUB1B overexpression appears associated with more aggressive behavior, increased proliferative activity, genomic complexity, chromosomal instability and DNA aneuploidy.…”

“…[36][37][38][39] Alterations in BUB1B have been documented in a number of cancers including breast cancer, lung cancer, colon cancer and gastric cancer. 37,38,[40][41][42][43][44] In these, BUB1B overexpression appears associated with more aggressive behavior, increased proliferative activity, genomic complexity, chromosomal instability and DNA aneuploidy. 37,[40][41][42][43]45,46 Interestingly, aneuploidy and complex karyotype are common finding in malignant peripheral nerve sheath tumors.…”

“…37,38,[40][41][42][43][44] In these, BUB1B overexpression appears associated with more aggressive behavior, increased proliferative activity, genomic complexity, chromosomal instability and DNA aneuploidy. 37,[40][41][42][43]45,46 Interestingly, aneuploidy and complex karyotype are common finding in malignant peripheral nerve sheath tumors. NEK2 is one of several kinases including CDK1/ cyclin B and Aurora A that are associated with the centrosome during cell cycle progression.…”

An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

“…High BubR1 expression was associated with shorter survival in oral malignant lesions and, interestingly, a possible correlation between HPV infection and BubR1 overexpression was suggested [63]. In contrast, another study shows that overexpression of BubR1 was associated with a less advanced tumor stage, but patients with overexpression of BubR1 showed shorter recurrence-free survival than those without it, making BubR1 a promising prognostic marker in patients with OSCC [64]. Curiously, the proliferation marker Ki-67 did not demonstrate a statistical significant correlation with BubR1 expression, contrasting with a previous report in patients with tonsillar carcinomas [65].…”