Objectives: This study compared digital study casts from tooth-borne and hybrid Rapid Maxillary Expansion (RME) using 3D virtual models scanned with a 3Shape laser scanner. Methods: A total of thirty patients with narrow maxilla were distributed into two equal groups using sequential randomization. The hybrid hyrax group (11 females and 4 males) had a mean age of 14.5 years, whereas the conventional hyrax group (10 females and 5 males) had a mean age of 13.96 years. Cone beam computed tomography and orthodontic casts were obtained before expansion and six months after the last activation. Eight parameters were measured, and the data was analyzed. Results: A paired t-test was used to evaluate the mean differences between pre-expansion and post-expansion measurements. Interdental distance (IDD) and rotations at first molar and premolars showed a statistically significant increase post-treatment compared to preoperative values, whereas arch depth and incisor inclination showed a statistically significant decrease. Furthermore, group B had statistically significant higher postoperative values and a greater IDD change (P≤0.05). Conclusion: RME with hybrid hyrax achieved skeletal effects and broaden the arch with only a slight increase in IDD compared to traditional RME. Regardless of the appliance, arch depth may be decreased following RME.