“…In the group with CML preceding Ph-negative MPN (13/24 cases), BM histology at CML presentation in 10/13 cases with available BM data was as follows: CML (CP) histology in 2/10 ( Kandarpa et al, 2017 ; Balducci et al, 2020 ), CML + fibrosis + hybrid MKs including both classical CML MKs with small and hypolobate nuclei and large hyperlobated forms in 3/10 ( Loghavi et al, 2015 ; Gilles et al, 2017 ; Guidotti et al, 2020 ), CML + atypical MKs in 2/10 ( Blouet et al, 2018 ; Da Costa et al, 2020 ), CML + fibrosis in 2/10 ( Diamond et al, 2016 ; Yoon et al, 2020 ), and grade 2 reticulin fibrosis with no other BM data in 1/10 ( Cabagnols et al, 2015 ). In this group, the emergence of the Ph-negative MPN phenotype usually occurred after TKI treatment and CML remission; the histology of BM at Ph-negative MPN emergence was available in 9/13 cases, and it was consistent with either PMF (4/9) ( Loghavi et al, 2015 ; Diamond et al, 2016 ; Kandarpa et al, 2017 ; Huo et al, 2023 ), ET (4/9) ( Dogliotti et al, 2017 ; Blouet et al, 2018 ; Balducci et al, 2020 ; Da Costa et al, 2020 ), or MPN, NOS (1/9) [ 25].…”