Buchwald coupling promoted benign synthesis of benzoxazine derivatives supported Cu complexes with their multipurpose potential in antimicrobial and catalytical fields

Synthesis of 2,4-Dicyanoalkylated Benzoxazines through the Radical-Mediated Cascade Cyclization of Isocyanides with AIBN under Metal- and Additive-Free Conditions

“…Cetilistat can be used as a gastrointestinal lipase inhibitor, a weight-loss pill, and a therapeutic drug for type II diabetes (Figure ). In addition, benzoxazines have extensive biological activities, such as antimicrobial, antitumor, and antimalarial . Therefore, the synthesis of benzoxazine and its derivatives or intermediates has attracted great attention by many organic and pharmaceutical chemists. − The radical cyclization of olefinic amides has become a highly efficient protocol for the synthesis of diverse functionalized benzoxazines (Scheme a).…”