Budding and tumor—infiltrating lymphocytes — combination of both parameters predicts survival in colorectal cancer and leads to new prognostic subgroups

Lang-Schwarz, Corinna; Melcher, Balint; Haumaier, Franziska; Lang-Schwarz, Klaus; Rupprecht, Thomas; Sterlacci, William

doi:10.1016/j.humpath.2018.05.010

Cited by 36 publications

(52 citation statements)

References 30 publications

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“…The highest prognostic significance of intratumoral TILs for both OS and DSS was reported with a cutoff point at 5%. This cutoff point was recently identified as the optimal cutoff point in colorectal cancer [29]. Moreover, in a recent study of lung cancer, tumors with TILs of 5% or less had the worst OS and DSS [27].…”

Section: Discussionmentioning

confidence: 93%

Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study

et al. 2018

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The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been studied recently in many cancers. For the first time in a nonendemic region, we have evaluated the prognostic value of TILs in a whole population-based nationwide cohort of nasopharyngeal carcinoma (NPC) in Finland. A total of 115 cases from Finnish hospitals were included. TILs were analyzed using hematoxylin and eosin-stained slides according to the criteria of the International Immuno-Oncology Biomarker Working Group. TILs were evaluated separately in stromal and tumor compartments. The log-rank test and univariable and multivariable analyses were used to compare survival in patients with tumors with low and high TILs. A significant positive correlation was observed between the occurrence of intratumoral and stromal TILs (P < .001). In multivariable analysis, NPC cases with low intratumoral TILs had poor overall survival with a hazard ratio (HR) of 2.55 and 95% confidence interval (95% CI) of 1.60 to 4.05 (P < .001). Cases with low intratumoral TILs also had poor disease-specific survival (HR, 2.02; 95% CI, 1.16-3.52; P = .015). Keratinized tumors with low intratumoral TILs were associated with an even poorer overall survival (HR, 3.94; 95% CI, 2.17-7.15; P < .001) and a poor disease-specific survival (HR, 2.97; 95% CI, 1.46-6.05; P = .009). Our study demonstrates that the evaluation of TILs is simple and can be assessed routinely in NPC.

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Section: Discussionmentioning

confidence: 93%

Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study

et al. 2018

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“…Four studies had overlapping cohorts [21][22][23][24], leaving twenty-eight independent studies with a total of 11423 patients [9,. Two studies did not find a significant survival difference for any H&E-based method [9,37], whereas the other twenty-six studies found significantly prolonged survival for patients with higher local inflammatory infiltrate with a total number of 10887 patients [25][26][27][28][29][30][31][32][33][34][35][36][38][39][40][41][42][43][44][45][46][47][48][49][50][51].…”

Section: Hande Assessment Of Inflammatory Infiltratementioning

confidence: 99%

“…There were nine independent studies that assessed TILs in this way in relation to survival in colon or colorectal cancer with a total of 5508 patients [27,33,36,[42][43][44][45][46][47], of which eight studies showed a positive association with survival, comprising 5343 patients [27,36,[42][43][44][45][46][47], while one showed no association [33]. There was no assessment of interobserver variability reported in any of the studies.…”

Section: Tils On Handementioning

confidence: 99%

“…Six studies assessed the presence of MSI: of which two found that TILs were independent of MSI in survival [36,46]; one found that MSI was not significant for survival [27]; while three did not include MSI in survival analysis [33,43,44]. Four studies assessed the density of TILs semiquantitatively [27,36,42,43], while five counted cells and assigned a cut-off [33,[44][45][46][47].…”

Section: Tils On Handementioning

confidence: 99%

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The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

Alexander

McMillan

Park

2020

Cancer Treatment Reviews

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The host anti-tumour inflammatory response is a strong prognostic indicator, and tumour infiltrating lymphocytes (TILs) are believed to have a complimentary role alongside TNM assessment in dictating future management. However, there is wide disagreement regarding the most efficacious and cost-effective method of assessment. Methods: A comprehensive literature search was performed of EMBASE, MedLine and PubMed as well as an assessment of references to identify all relevant studies relating to the assessment of the peri-tumoural inflammatory response or TILs and prognosis in colorectal cancer (CRC). A meta-analysis was performed of 67 studies meeting the REMARK criteria using RevMan software. Results: Intratumoural assessment of both CD3 and CD8 in CRC were significant for disease-free survival (DFS) (combined HRs 0.46; 95%CI: 0.39-0.54 and 0.54; 95%CI: 0.45-0.65), as well as overall survival (OS) and disease-specific survival (DSS). The same was true for assessment of CD3 and CD8 at the invasive margin (DFS: combined HRs 0.45; 95%CI: 0.33-0.61 and 0.51; 95%CI: 0.41-0.62). However, similar fixed effects summaries were also observed for H&E-based methods, like Klintrup-Makinen grade (DFS: HR 0.62; 95%CI: 0.43-0.88). Furthermore, inflammatory assessments were independent of MSI status. Conclusion: The evidence suggests that it is the density of a coordinated local inflammatory infiltrate that confers survival benefit, rather than any individual immune cell subtype. Furthermore, the location of individual cells within the tumour microenvironment does not appear to influence survival. The authors advocate a standardised assessment of the local inflammatory response, but caution against emphasizing the importance of any individual immune cell subtype.

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“…A presença de infiltrado inflamatório peritumoral tem sido relacionada com prognóstico em diversos tumores, como pulmão 62 , mama 63 , trato gênitourinário 64 , estômago 65 , colorretal [66][67][68] , entre outros. Nas MHCCR, a presença de infiltrado inflamatório ou de células como CD4+, também tem sido associada a um melhor prognóstico 52,58,69,70 .…”

Section: Lista De Abreviaturasunclassified

A Importância Prognóstica Dos Grupamentos Pouco Diferenciados E Brotamentos Tumorais Nas Metástases Hepáticas Do Câncer Colorretal

Fonseca¹,

Mello²,

Faraj³

et al. 2017

ABCDExpress

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Budding and tumor—infiltrating lymphocytes — combination of both parameters predicts survival in colorectal cancer and leads to new prognostic subgroups

Cited by 36 publications

References 30 publications

Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study

Tumor-infiltrating lymphocytes associate with outcome in nonendemic nasopharyngeal carcinoma: a multicenter study

The local inflammatory response in colorectal cancer – Type, location or density? A systematic review and meta-analysis

A Importância Prognóstica Dos Grupamentos Pouco Diferenciados E Brotamentos Tumorais Nas Metástases Hepáticas Do Câncer Colorretal

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