Buddy Study: Partners for better health in adolescents with type 2 diabetes

Sylvetsky, Allison C.; Nandagopal, R.; Nguyen, Tammy; Abegg, Marisa R.; Nagarur, Mahathi; Kaplowitz, Paul B.; Rother, Kristina I.

doi:10.4239/wjd.v6.i18.1355

Cited by 11 publications

(36 citation statements)

References 44 publications

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“…In addition, prior studies demonstrate that peer support may improve blood glucose control [23,24], peer-based support may be as effective for weight loss as coach-based support [25], and that online discussion boards can be supportive for weight loss [26]. Therefore, the program encourages social support by matching new participants of the program to a “buddy,” a previous graduate of the program, based on similar demographics including age, gender, and their self-selected goal.…”

Section: Methodsmentioning

confidence: 99%

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Saslow¹,

Summers²,

Aikens³

et al. 2018

JMIR Diabetes

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BackgroundType 2 diabetes mellitus has serious health consequences, including blindness, amputation, stroke, and dementia, and its annual global costs are more than US $800 billion. Although typically considered a progressive, nonreversible disease, some researchers and clinicians now argue that type 2 diabetes may be effectively treated with a carbohydrate-reduced diet.ObjectiveOur objective was to evaluate the 1-year outcomes of the digitally delivered Low-Carb Program, a nutritionally focused, 10-session educational intervention for glycemic control and weight loss for adults with type 2 diabetes. The program reinforces carbohydrate restriction using behavioral techniques including goal setting, peer support, and behavioral self-monitoring.MethodsThe study used a quasi-experimental research design comprised of an open-label, single-arm, pre-post intervention using a sample of convenience. From adults with type 2 diabetes who had joined the program and had a complete baseline dataset, we randomly selected participants to be followed for 1 year (N=1000; mean age 56.1, SD 15.7 years; 59.30% (593/1000) women; mean glycated hemoglobin A1c (HbA1c) 7.8%, SD 2.1%; mean body weight 89.6 kg, SD 23.1 kg; taking mean 1.2, SD 1.01 diabetes medications).ResultsOf the 1000 study participants, 708 (70.80%) individuals reported outcomes at 12 months, 672 (67.20%) completed at least 40% of the lessons, and 528 (52.80%) completed all lessons of the program. Of the 743 participants with a starting HbA1c at or above the type 2 diabetes threshold of 6.5%, 195 (26.2%) reduced their HbA1c to below the threshold while taking no glucose-lowering medications or just metformin. Of the participants who were taking at least one hypoglycemic medication at baseline, 40.4% (289/714) reduced one or more of these medications. Almost half (46.40%, 464/1000) of all participants lost at least 5% of their body weight. Overall, glycemic control and weight loss improved, especially for participants who completed all 10 modules of the program. For example, participants with elevated baseline HbA1c (≥7.5%) who engaged with all 10 weekly modules reduced their HbA1c from 9.2% to 7.1% (P<.001) and lost an average of 6.9% of their body weight (P<.001).ConclusionsEspecially for participants who fully engage, an online program that teaches a carbohydrate-reduced diet to adults with type 2 diabetes can be effective for glycemic control, weight loss, and reducing hypoglycemic medications.

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Section: Methodsmentioning

confidence: 99%

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Saslow¹,

Summers²,

Aikens³

et al. 2018

JMIR Diabetes

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“…[66] The idea and concept of MPE have been accepted and applied by a large number of scholars in the medical and public health science literature. [42,64,67–134] Its importance has been discussed in well-established international meetings,[135–137] as well as the International MPE Meeting Series that has a focus on MPE. [138]…”

Section: Molecular Pathological Epidemiology (Mpe)mentioning

confidence: 99%

Integration of molecular pathology, epidemiology and social science for global precision medicine

Nishi

Milner

Giovannucci

et al. 2015

Expert Review of Molecular Diagnostics

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Summary The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations, and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial, and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors, and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference, and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology, and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors, and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging, and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science.

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“…TExT-MED+FANS is unique in that ED patients with diabetes are enrolled with a loved one, capitalizing on existing support relationships and augmenting the support already provided. This contrasts with work in which patient were paired with previously unknown peers or lay supporters, 7,10,[47][48][49] which have been positively received, had moderate impact on intentions and behaviors, but showed heterogenous results on glycemic control. Latino populations have shown promise with these interventions, potentially due to the importance of family in health decisions and disease management for many Latinos.…”

Section: Discussionmentioning

confidence: 95%

Design and patient characteristics of the randomized controlled trial TExT-MED + FANS A test of mHealth augmented social support added to a patient-focused text-messaging intervention for emergency department patients with poorly controlled diabetes

Burner

Mercado

Hernandez-Saenz

et al. 2019

Contemporary Clinical Trials

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Buddy Study: Partners for better health in adolescents with type 2 diabetes

Abstract: Our approach, effective in adults with type 2 diabetes, was unsuccessful among adolescents and emphasizes the need for innovative strategies for diabetes treatment in adolescent patients.

Cited by 11 publications

References 44 publications

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Integration of molecular pathology, epidemiology and social science for global precision medicine

Design and patient characteristics of the randomized controlled trial TExT-MED + FANS A test of mHealth augmented social support added to a patient-focused text-messaging intervention for emergency department patients with poorly controlled diabetes

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Buddy Study: Partners for better health in adolescents with type 2 diabetes

Abstract: Our approach, effective in adults with type 2 diabetes, was unsuccessful among adolescents and emphasizes the need for innovative strategies for diabetes treatment in adolescent patients.

Cited by 11 publications

References 44 publications

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Outcomes of a Digitally Delivered Low-Carbohydrate Type 2 Diabetes Self-Management Program: 1-Year Results of a Single-Arm Longitudinal Study

Integration of molecular pathology, epidemiology and social science for global precision medicine

Design and patient characteristics of the randomized controlled trial TExT-MED + FANS A test of mHealth augmented social support added to a patient-focused text-messaging intervention for emergency department patients with poorly controlled diabetes

Contact Info

Product

Resources

About

Design and patient characteristics of the randomized controlled trial TExT-MED + FANS A test of mHealth augmented social support added to a patient-focused text-messaging intervention for emergency department patients with poorly controlled diabetes