“…Negative-pressure wound therapy may have role in the treatment debilitating complex chronic ulcers in patients with TAO [149][150][151]. Given the lack of supportive data, hyperbaric oxygen therapy should be considered only in patients with ischemic ulcers, osteomyelitis, or necrotizing fasciitis who are refractory to other forms of treatment [112,[152][153][154][155][156][157][158]. Daily arterial flow pump therapy [159] or intermittent pneumatic compression pump [160] may relieve symptoms when cessation of smoking is achieved.…”