Bugs, hosts and ICU environment: Countering pan-resistance in nosocomial microbiota and treating bacterial infections in the critical care setting

Synthesis, characterization and in vitro photodynamic antimicrobial activity of basic amino acid–porphyrin conjugates

“…1 (1 equiv, 0.20 mmol) in THF (5 mL). Then the reaction mixture was allowed to stir for 24 h at 463 room temperature with TLC monitoring.…”

“…The extract was dried with anhydrous sodium sulfate and evaporated in a vacuum. The white solid (30.2 g, 85% yield) was obtained 1. H NMR (300 MHz, DMSO-d 6 ) δ 1.35 (s, 9H), 1.56 (s, 9H), 2.74-2.91 (m, 2H), 4.13-4.21 (m, 1H), 7.02 (d, J = 9.0 Hz, 1H), 7.22 (s, 1H), 8.11 (s, 1H).…”

“…ACCEPTED MANUSCRIPT 23 72.0 mg, 95% yield; mp > 300 °C 1. H NMR (300 MHz, DMSO-d 6 ) δ −2.90 (s, 2H), 1.46-1.57 (m, 501 4H), 1.76 (m, 2H), 2.62 (t, J = 6.0 Hz, 2H), 3.34 (br, 4H), 3.46 (t, J = 6.0 Hz, 1H), 7.80-7.82 (m, 502 9H), 8.08-8.22 (m, 11H), 8.81-8.89 (m, 8H).…”

Mitral valve prolapse caused from ruptured mitral chordae tendineae due to an infective endocarditis in cancer patient

“…Moreover oncosurgery represents a challenge for cardiologist [24] and preoperative cardiological assessment is the cornerstone of the modern oncosurgery as well as efficacious anesthesiological evaluation [24][25][26]. In the emerging scenario of concomitant problems and diseases [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41], physicians should be familiar with available drugs, environmental epidemiology and patient factors [24][25][26][27][28][29][30][31][32][33][34][35] as well as with new emerging findings with regard to use of cardiovascular drugs [27,28,[31][32][33][34][41][42][43]. Ruptured [44] mitral chordae tendineae are increasingly reported as an important cause of mitral regurgitation [45,46] being a common unrecognized contributo...…”

The chance finding of an atrial septal defect in a cancer patient

“…Oncosurgery represents a challenge for cardiologist [23] and preoperative cardiological assessment is the cornerstone of the modern oncosurgery as well as efficacious anesthesiological evaluation [23][24][25]. In the emerging scenario of concomitant problems and diseases [23][24][25][26][27][28][29][30][31][32][33], phisicians should be familiar with available drugs, environmental epidemiology and patient factors [23][24][25][26][27][28][29][30][31][32][33][34] as well as with new emerging findings regard use of cardiovascular drugs [26,27,[30][31][32][33]35]. Increasing evidence suggests that the role of infective endocarditis antibiotic prophylaxis remains a dark side of the cardio-oncology prevention [1,11,12] as well as the role of the thromboembolism prophylaxis [19].…”