2023
DOI: 10.1021/acs.analchem.3c03512
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Building a Nucleic Acid Nanostructure with DNA–Epitope Conjugates for a Versatile Approach to Electrochemical Protein Detection

Asanka Gurukandure,
Subramaniam Somasundaram,
Amanda S. N. Kurian
et al.

Abstract: The recent surge of effort in nucleic-acid-based electrochemical (EC) sensors has been fruitful, yet there remains a need for more generalizable EC platforms for sensing multiple classes of clinically relevant targets. We recently reported a nucleic acid nanostructure for simple, economical, and more generalizable EC readout of a range of analytes, including small molecules, peptides, proteins, and antibodies. The nanostructure is built through on-electrode enzymatic ligation of three oligonucleotides for atta… Show more

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