Bulk Modification of Poly(lactide) (PLA) via Copolymerization with Poly(propylene glycol) Diglycidylether (PPGDGE)

Castillejos, Sandra; Cerna, Jorge; Meléndez, Francisco J.; Castro, María Eugenia; Aguilar, Rogelio Ramos; Márquez‐Beltrán, César

doi:10.3390/polym10111184

Cited by 16 publications

(11 citation statements)

References 45 publications

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“…The FTIR spectra shown in Figure 4 confirmed the findings of the XPS experiment, though no new bands occurred. Typical characteristic PLA peaks were present: 2994-2944 cm −1 (C-H), 1744 cm −1 (C=O), 1450 cm −1 , and 1360 cm −1 (-CH 3 ), as well as O-C=O stretching at 1185 cm −1 [31,32]. In order to display the changes in the abundancy of carbonyl groups, the relative intensities of the C=O/C-H bands present at 1744 and 1360 cm −1 , respectively, were compared.…”

Section: Fourier-transform Infrared Spectroscopymentioning

confidence: 99%

Discharge Plasma Treatment as an Efficient Tool for Improved Poly(lactide) Adhesive–Wood Interactions

et al. 2021

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Poly(lactide) (PLA) films obtained by thermoforming or solution-casting were modified by diffuse coplanar surface barrier discharge plasma (300 W and 60 s). PLA films were used as hot-melt adhesive in joints in oak wood. It was demonstrated that lap shear strength increased from 3.4 to 8.2 MPa, respectively, for the untreated and plasma-treated series. Pull-off tests performed on particleboard for the untreated and treated PLA films showed 100% cohesive failure. Pull-off strength tests on solid oak demonstrated adhesion enhancement from 3.3 MPa with the adhesion failure mode to 6.6 MPa with the cohesion failure mode for untreated and treated PLA. XPS revealed that carbonyl oxygen content increased by two-to-three-fold, which was confirmed in the Fourier-transform infrared spectroscopy experiments of the treated PLA. The water contact angle decreased from 66.4° for the pristine PLA to 49.8° after treatment. Subsequently, the surface free energy increased from 47.9 to 61.05 mJ/m2. Thus, it was clearly proven that discharge air plasma can be an efficient tool to change surface properties and to strengthen adhesive interactions between PLA and woody substrates.

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Section: Fourier-transform Infrared Spectroscopymentioning

confidence: 99%

Discharge Plasma Treatment as an Efficient Tool for Improved Poly(lactide) Adhesive–Wood Interactions

et al. 2021

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“…Some strategies including grafting and copolymerization techniques have been adopted for improving the degradation rate of PLLA to accelerate the degradation of HAP/PLLA composite scaffold [ [15] , [16] , [17] , [18] ]. Nugroho et al [ 15 ] grafted polymer monomer acrylic acid (AA) on the surface of PLLA, and found that the grafted polymer chains could induce a local acidic environment, which in turn catalyzed the degradation of PLLA.…”

Section: Introductionmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

277

124

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The incorporation of hydroxyapatite (HAP) into poly- l -lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone. While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body fluid. In this study, biodegradable polymer poly (glycolic acid) (PGA) was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the degradation. The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3% to 25.0% after immersion for 28 days, owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains. Moreover, a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix, which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite growth. Cytocompatibility tests exhibited a good osteoblast adhesion, spreading and proliferation, suggesting the scaffold provided a suitable environment for cell cultivation. Furthermore, the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue, and both ends of defect region were bridged after 8 weeks of implantation.

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“…Poly-l-lactic acid (PLLA) has become one of the main bone scaffold materials due to its advantages of good biocompatibility and easy processing [ 1 , 2 , 3 ]. Nevertheless, the low cellular activity limits its application in bone tissue engineering due to the lacking of active functional groups and weak cell affinity [ 4 , 5 , 6 , 7 ]. For enhancing cellular activity, researchers have added various cell growth factors, such as bone morphogenetic protein (BMP), transforming growth factor-beta (TGF-β), fibroblast growth factor, and so on [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe3O4 nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe3O4 nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe3O4 presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe3O4 nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe3O4 scaffold with good magnetic properties is of great potential for bone tissue engineering applications.

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Bulk Modification of Poly(lactide) (PLA) via Copolymerization with Poly(propylene glycol) Diglycidylether (PPGDGE)

Cited by 16 publications

References 45 publications

Discharge Plasma Treatment as an Efficient Tool for Improved Poly(lactide) Adhesive–Wood Interactions

Discharge Plasma Treatment as an Efficient Tool for Improved Poly(lactide) Adhesive–Wood Interactions

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

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