Buprenorphine, a partial opioid agonist, prevents modulation of H-reflex induced by pulsed electromagnetic stimulation in spinal cord injured rats

Arvanian, Victor L.; Liang, Li; Tesfa, Asrat; Fahmy, Magda; Petrosyan, Hayk A.

doi:10.1016/j.neulet.2022.136583

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Finally, the H-reflex recordings, which we carried out in all young animals at the termination of behavioral experiments (5 weeks post-operatively), have proved the impaired sensory-motor integration in all injured animals to a similar extent between the groups. Notably, the observed changes in the H/M ratio were quantitatively similar to those reported by others [ 46 , 47 ]. The prevalent group of young SCI rats consisted of animals whose motor deficit after a mild injury recovered with time.…”

Section: Discussionsupporting

confidence: 90%

Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury

et al. 2022

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Motor disability is a common outcome of spinal cord injury (SCI). The recovery of motor function after injury depends on the severity of neurotrauma; motor deficit can be reversible, at least partially, due to the innate tissue capability to recover, which, however, deteriorates with age. Pain is often a comorbidity of injury, although its prediction remains poor. It is largely unknown whether pain can attend motor dysfunction. Here, we implemented SCI for modelling severe and moderate neurotrauma and monitored SCI rats for up to 5 months post-injury to determine the profiles of both motor deficit and nociceptive sensitivity. Our data showed that motor dysfunction remained persistent after a moderate SCI in older animals (5-month-old); however, there were two populations among young SCI rats (1 month-old) whose motor deficit either declined or exacerbated even more over 4–5 weeks after identical injury. All young SCI rats displayed changed nociceptive sensitivity in thermal and mechanical modalities. The regression analysis of the changes revealed a population trend with respect to hyper- or hyposensitivity/motor deficit. Together, our data describe the phenotypes of motor deficit and pain, the two severe complications of neurotrauma. Our findings also suggest the predictability of motor dysfunction and pain syndromes following SCI that can be a hallmark for long-term rehabilitation and recovery after injury.

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Section: Discussionsupporting

confidence: 90%

Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury

et al. 2022

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Spinal Magnetic Stimulation to Treat Chronic Back Pain: A Feasibility Study In Veterans

Tesfa,

Petrosyan,

Fahmy

et al. 2024

Pain Manag.

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Aim: Chronic low back pain represents a significant societal problem leading to increased healthcare costs and quality of life. This study was designed to evaluate the feasibility and effectiveness of non-invasive spinal electromagnetic simulation (SEMS) to treat nonspecific chronic low back pain (CLBP). Methods: A single-site prospective study was conducted to evaluate SEMS in reducing pain and improving disability. A total of 17 patients received SEMS two to three sessions a week. The Numeric Rating Scale and the Modified Oswestry Disability Questionnaire were used to assess pain and disability. Results: Participants receiving SEMS exhibited statistically significant reductions in pain and disability. Conclusion: Current results suggest that non-invasive SEMS can be an effective treatment in reducing pain and improving disability associated with CLBP.

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Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy

Han,

Calcutt,

Zhou

2024

Diabetes Metab J

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Measurement of the rate-dependent depression (RDD) of the Hoffmann (H) reflex, a technique developed over half a century ago, is founded on repeated stimulation of the H-reflex with tracking of sequentially evoked H-wave amplitudes in the resulting electromyogram. RDD offers insight into the integrity of spinal reflex pathways and spinal inhibitory regulation. Initially, RDD was predominantly utilized in the mechanistic exploration and evaluation of movement disorders characterized by spasticity symptoms, as may occur following spinal cord injury. However, there is increasing recognition that sensory input from the periphery is modified at the spinal level before ascending to the higher central nervous system and that some pain states can arise from, or be exaggerated by, disruption of spinal processing via a mechanism termed spinal disinhibition. This, along with the urgent clinical need to identify biological markers of pain generator and/or amplifier sites to facilitate targeted pain therapies, has prompted interest in RDD as a biomarker for the contribution of spinal disinhibition to neuropathic pain states. Current research in animals and humans with diabetes has revealed specific disorders of spinal GABAergic function associated with impaired RDD. Future investigations on RDD aim to further elucidate its underlying pathways and enhance its clinical applications.

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Buprenorphine, a partial opioid agonist, prevents modulation of H-reflex induced by pulsed electromagnetic stimulation in spinal cord injured rats

Cited by 3 publications

References 28 publications

Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury

Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury

Spinal Magnetic Stimulation to Treat Chronic Back Pain: A Feasibility Study In Veterans

Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy

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