2014
DOI: 10.1093/jat/bku060
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Buprenorphine Detection in Urine Using Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Cloned Enzyme Donor Immunoassay (ThermoFisher) and Homogeneous Enzyme Immunoassay (Immunalysis)

Abstract: A sensitive liquid chromatographic-high-resolution mass spectrometric (LC-HR-MS) assay for buprenorphine and its urinary metabolites has been developed that requires minimal sample preparation. The results obtained have been compared with those given by (i) cloned enzyme donor immunoassay (CEDIA) and (ii) homogeneous enzyme immunoassay (HEIA) in the analysis of patient urines submitted for buprenorphine analysis. Centrifuged urine (100 µL) was diluted with internal standard solution (25 µL) + LC eluent (875 µL… Show more

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Cited by 11 publications
(1 citation statement)
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“…An increasing number of labs now have access to HRMS in addition to conventional triple quadrupole and ion trap mass spectrometers (Belsey, Couchman, & Flanagan, 2014;Grabenauer, Krol, Wiley, & Thomas, 2012;Ojanpera, Kolmonen, & Pelander, 2012). Q-Orbitrap based HRMS offers comparable quantitation performance with sensitivity at sub ng mL À1 levels.…”
Section: Compoundsmentioning
confidence: 99%
“…An increasing number of labs now have access to HRMS in addition to conventional triple quadrupole and ion trap mass spectrometers (Belsey, Couchman, & Flanagan, 2014;Grabenauer, Krol, Wiley, & Thomas, 2012;Ojanpera, Kolmonen, & Pelander, 2012). Q-Orbitrap based HRMS offers comparable quantitation performance with sensitivity at sub ng mL À1 levels.…”
Section: Compoundsmentioning
confidence: 99%