Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children

Furuta, Takahisa; Hasegawa, Shunji; Mizutani, Makoto; Iwai, Takashi; Ohbuchi, Noriko; Kawano, Shoji; Tashiro, Norimichi; Uchida, Masashi; Hasegawa, Motoharu; Motoyama, Masashi; Sekino, Takaomi; Nakatsuka, Kenji; Ichihara, Kiyoshi; Shirabe, Komei; Ohga, Shouichi

doi:10.1097/inf.0000000000002038

Cited by 15 publications

(18 citation statements)

References 19 publications

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“…Given the Th2 polarization in respiratory secretions [16][17][18] and the reported association between hMPV hospitalizations and asthmatic children [12,26,27], we hypothesized that children of asthmatic mothers would be overrepresented among patients infected with the virus experiencing LTD.…”

Section: A Subgroup Of Infants At High Risk For Life-threatening Hmpvmentioning

confidence: 99%

Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

Libster

Esteban

Bianchi

et al. 2020

The Journal of Infectious Diseases

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Background. Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between these pathogens have been noted, suggesting the degree of illness may vary in different populations. Moreover, a potential association between hMPV and asthma also suggests that hMPV may preferentially affect asthmatic subjects.Methods. In a population-based surveillance study in children aged <2 years admitted for severe LRTI in Argentina, nasopharyngeal aspirates were tested by RT-PCR for hMPV, RSV, influenza A, and human rhinovirus.Results. Of 3947 children, 383 (10%) were infected with hMPV. The hospitalization rate for hMPV LRTI was 2.26 per 1000 children (95% confidence interval [CI], 2.04-2.49). Thirty-nine (10.2%) patients infected with hMPV experienced life-threatening disease (LTD; 0.23 per 1000 children; 95% CI, .16-.31/1000), and 2 died (mortality rate 0.024 per 1000; 95% CI, .003-.086). In hMPV-infected children birth to an asthmatic mother was an increased risk for LTD (odds ratio, 4.72; 95% CI, 1.39-16.01). We observed a specific interaction between maternal asthma and hMPV infection affecting risk for LTD.Conclusions. Maternal asthma increases the risk for LTD in children <2 years old hospitalized for severe hMPV LRTI.

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Section: A Subgroup Of Infants At High Risk For Life-threatening Hmpvmentioning

confidence: 99%

Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

Libster

Esteban

Bianchi

et al. 2020

The Journal of Infectious Diseases

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“…The burden attributed to seasonal influenza virus has long received most of the attention [2], but the involvement of non-influenza respiratory viruses (NIRVs), such as respiratory syncytial virus and human metapneumovirus, is increasingly documented [3,4]. However, the burden of NIRVs [5–7] compared to seasonal influenza [8] is rarely estimated. These data would allow to better understand the need for enhanced surveillance of these viruses during winter seasons with the aim of improving patient management.…”

Section: Introductionmentioning

confidence: 99%

“…However, the burden of NIRVs [5][6][7] compared to seasonal influenza [8] is rarely estimated. These data would allow to better understand the need for enhanced surveillance of these viruses during winter seasons with the aim of improving patient management.…”

Section: Introductionmentioning

confidence: 99%

Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, 2015-2019, Belgium

Subissi

Bossuyt

Gerard

et al. 2021

Preprint

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BACKGROUNDSeasonal influenza-like illness (ILI) affects millions of people yearly. Severe acute respiratory infections (SARI), mainly caused by influenza, are a leading cause of hospitalisation and mortality. Increasing evidence indicates that non-influenza respiratory viruses (NIRVs) also contribute to the burden of SARI. In Belgium, SARI surveillance by a network of sentinel hospitals is ongoing since 2011.AIMHere, we report the results of using in-house multiplex PCRs for the detection of a flexible panel of viruses in respiratory ILI and SARI samples and the estimated incidence rates of SARI associated to each virus.METHODSILI was defined as an infection with onset of fever and cough or dyspnoea. SARI was defined as an infection requiring hospitalization with onset of fever and cough or dyspnoea within the previous 10 days. Samples were collected during four winter seasons and tested by multiplex RT-qPCRs for influenza virus and NIRVs. Using catchment population estimates, incidence rates of SARI associated to each virus were calculated.RESULTSOne third of the SARI cases were positive for NIRVs, reaching 49.4% among children under fifteen. In children under five, incidence rates of NIRV-associated SARI were double that of influenza (103.4 versus 57.6 per 100000 person-months), with NIRV co-infections, respiratory syncytial viruses, human metapneumoviruses and picornaviruses contributing the most (33.1, 13.6, 15.8 and 18.2 per 100000 person-months, respectively).CONCLUSIONEarly testing for NIRVs could be beneficial to clinical management of SARI patients, especially in children under five, for whom the burden of NIRV-associated disease exceeds that of influenza.

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“…HMPV, along with influenza and respiratory syncytial virus (RSV), causes a significant worldwide socio-economic burden and mostly affects infants and children younger than 5 years of age [ 2 , 3 ]. HMPV was shown to have an even higher impact than RSV on the development of hypoxic respiratory illnesses in asthmatic children [ 4 ]. Globally, HMPV accounts for 6–40% of all hospitalized and outpatient children with an acute respiratory illness [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Prospects of and Barriers to the Development of Epitope-Based Vaccines against Human Metapneumovirus

2020

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Human metapneumovirus (HMPV) is a major cause of respiratory illnesses in children, the elderly and immunocompromised patients. Although this pathogen was only discovered in 2001, an enormous amount of research has been conducted in order to develop safe and effective vaccines to prevent people from contracting the disease. In this review, we summarize current knowledge about the most promising experimental B- and T-cell epitopes of human metapneumovirus for the rational design of HMPV vaccines using vector delivery systems, paying special attention to the conservation of these epitopes among different lineages/genotypes of HMPV. The prospects of the successful development of an epitope-based HMPV vaccine are discussed in the context of recent findings regarding HMPV’s ability to modulate host immunity. In particular, we discuss the lack of data on experimental human CD4 T-cell epitopes for HMPV despite the role of CD4 lymphocytes in both the induction of higher neutralizing antibody titers and the establishment of CD8 memory T-cell responses. We conclude that current research should be focused on searching for human CD4 T-cell epitopes of HMPV that can help us to design a safe and cross-protective epitope-based HMPV vaccine.

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Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children

Abstract: Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children.

Cited by 15 publications

References 19 publications

Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

Role for Maternal Asthma in Severe Human Metapneumovirus Lung Disease Susceptibility in Children

Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, 2015-2019, Belgium

Prospects of and Barriers to the Development of Epitope-Based Vaccines against Human Metapneumovirus

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