Burden of Persistent Vomiting With Cannabis Use Disorder: Report From 55,549 Hospitalizations in the United States

Patel, Rikinkumar S; Patel, Jaiminkumar; Jaladi, Paul Rahul; Bhimanadham, Narmada Neerja; Imran, Sundus; Tankersley, William E.

doi:10.1016/j.psym.2019.07.003

Cited by 15 publications

(15 citation statements)

References 18 publications

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“…Mood and anxiety disorders, suicidal behaviors, and psychotic disorders were significantly associated with pediatric POD inpatients having CUD [22]. Youth with CUD at an earlier age have a greater risk of long-lasting cognitive impairment and several psychiatric and medical conditions [23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Pankaj

Oraka²,

Caraballo-Rivera

et al. 2020

Cureus

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Our first goal is to evaluate the prevalence of hospital admissions for prescription opioid overdose (POD) in pediatric inpatients, and next goal is to measure the independent association between cannabis use disorders (CUD) and POD. Methods We used the nationwide inpatient sample (NIS) and included 27,444,239 pediatric inpatients (age ≤ 18 years), and 10,562 (0.04%) were managed primarily for POD. The odds ratio (OR) of the association of variables in POD inpatients was measured using the binomial logistic regression model that was adjusted for demographic confounders and psychiatric comorbidities. Results Adolescents have higher odds (OR 10.75, 95% CI 10.16-11.36) of POD-related hospitalization compared to children ≤ 12 years. Whites formed the significant proportion (67%), and those from low-income families (<50th percentile) had higher likelihood for POD-related hospitalization. The most prevalent psychiatric comorbidities were mood disorders (44.3%) and anxiety disorders (14.6%). Prevalent comorbid substance use disorders (SUDs) included cannabis (14.2%), tobacco (13.1%), and opioid (9.4%). A higher odds of association with POD-related hospitalizations were seen in pediatric inpatients with comorbid opioid (

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Section: Discussionmentioning

confidence: 99%

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Pankaj

Oraka²,

Caraballo-Rivera

et al. 2020

Cureus

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“…Patients aged between 16 to 50 years who were discharged after an emergency department-based hospitalization with a primary diagnosis of CUD and other diagnoses of intractable vomiting were included in the analysis [7,9-10]. The cannabis abuse/dependence diagnoses were identified using the following ICD-9-CM codes: 304.30, 304.31, 304.32, 305.20, 305.21, and 305.22 [3,7,9,11]. Also, intractable vomiting was identified using ICD-9-CM code 536.2 [3,7,9].…”

Section: Methodsmentioning

confidence: 99%

“…The cannabis abuse/dependence diagnoses were identified using the following ICD-9-CM codes: 304.30, 304.31, 304.32, 305.20, 305.21, and 305.22 [3,7,9,11]. Also, intractable vomiting was identified using ICD-9-CM code 536.2 [3,7,9]. Patients below 16 years and above 50 years of age were excluded to limit our analysis to the middle 90th percentile of the cannabis users in the US [3,12].…”

Section: Methodsmentioning

confidence: 99%

“…Also, intractable vomiting was identified using ICD-9-CM code 536.2 [3,7,9]. Patients below 16 years and above 50 years of age were excluded to limit our analysis to the middle 90th percentile of the cannabis users in the US [3,12].…”

Section: Methodsmentioning

confidence: 99%

“…Cannabis use has increased majorly in males and unemployed individuals [2]. Intractable vomiting or hyperemesis has been shown to have a significant association with cannabis abuse or dependence due to which this area has been studied more frequently [3-4]. A nationwide study by Patel et al found that cannabis abuse increases the risk of persistent vomiting-related hospitalization by 60.9% after controlling for confounding risk factors and comorbid substance use disorders [3].…”

Section: Introductionmentioning

confidence: 99%

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Burden of Comorbidities in Hospitalizations for Cannabis Use-associated Intractable Vomiting during Post-legalization Period

Madireddy

Patel

Ravat

et al. 2019

Cureus

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The aim of this study was to observe the trends of intractable vomiting and cannabis use disorder (CUD) with demographic characteristics, medical and psychiatric comorbidities, and hospitalization outcomes. Methods We conducted a retrospective cohort study using the nationwide inpatient sample (2010 to 2014). Patients aged 16-50 years discharged with a primary diagnosis of intractable vomiting and CUD were included (N = 9,601). We used the linear-by-linear association chi-square test and independent-sample T-test for measuring the categorical and continuous data, respectively.

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Cannabinoid Use Among Liver Transplant Recipients

Yan

Forman

2021

Liver Transpl.

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The effect of cannabinoids on liver transplant outcomes is an area of active research. We aimed to investigate marijuana (MJ) and cannabidiol (CBD) use among liver transplant recipients at the University of Colorado Hospital (UCH), specifically prevalence, habits, and predictors of use. Liver transplant recipients followed at UCH with valid email addresses were sent an informed consent postcard and survey invitation. This exploratory survey was conducted using REDCap. IBM SPSS Statistics software was used for statistical analysis. Of 1227 recipients who were sent surveys, 538 people responded. On average, respondents were 59 years old, with 63.7% male and 81.7% White. Hepatitis C virus (HCV; 30.4%) and alcohol use (17.7%) were the most common etiologies of liver disease. Among respondents, 23.8% reported current MJ use. Methods of use included smoking (72.4%), ingestion (55.3%), and vaporization (31.7%). Top reasons for MJ use were recreation (56.5%), anxiety (54.8%), and pain (53.2%). Among respondents, 21.0% currently used CBD, usually in the form of creams or lotions (58.9%) and to relieve pain (84.9%) and anxiety (31.1%). In multivariable analysis, age (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.923-0.959; P < 0.001), diabetes mellitus (OR, 0.357; 95% CI, 0.171-0.746; P = 0.01), HCV cirrhosis (OR, 3.949; 95% CI, 2.281-6.835; P < 0.001), alcohol-related cirrhosis (OR, 2.101; 95% CI, 1.202-3.671; P = 0.01), and current tobacco use (OR, 2.918; 95% CI, 1.065-7.990; P = 0.04) were significant predictors of MJ use. Our study shows that cannabinoid use after liver transplant is common. MJ use is associated with decreasing age, alcohol-related and HCV cirrhosis, and tobacco use. Anxiety, pain, and recreation were top reasons for its use. Transplant teams should address reasons why their patients use MJ and CBD and develop programs to mitigate anxiety and pain after transplant. Further studies are needed to examine effects of cannabinoids on liver transplant outcomes.

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Burden of Persistent Vomiting With Cannabis Use Disorder: Report From 55,549 Hospitalizations in the United States

Cited by 15 publications

References 18 publications

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Recreational Cannabis Use and Risk of Prescription Opioid Overdose: Insights from Pediatric Inpatients

Burden of Comorbidities in Hospitalizations for Cannabis Use-associated Intractable Vomiting during Post-legalization Period

Cannabinoid Use Among Liver Transplant Recipients

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