Buried treasure: Unlocking the secrets of medicinal mushrooms

Walton, Emma Louise

doi:10.4103/2319-4170.146538

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Ganoderic acids, ganodermanontriol, ganoderiol, polysaccharides, germanium, triterpenoids, nucleotides and nucleosides, β-glucan Anti-metastatic, anti-tumour, anti-viral, anti-HIV, immunomodulatory, antibiotic properties, liver protection, prevents cholesterol synthesis [22,23] Lentinula edodes (Shiitake)…”

Section: Mushroom (Common Name) Bioactive Compounds Health Benefits Referencesmentioning

confidence: 99%

Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects

Kumar

Mehra

Guiné

et al. 2021

Foods

125

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Mushrooms are well-known functional foods due to the presence of a huge quantity of nutraceutical components. These are well recognized for their nutritional importance such as high protein, low fat, and low energy contents. These are rich in minerals such as iron, phosphorus, as well as in vitamins like riboflavin, thiamine, ergosterol, niacin, and ascorbic acid. They also contain bioactive constituents like secondary metabolites (terpenoids, acids, alkaloids, sesquiterpenes, polyphenolic compounds, lactones, sterols, nucleotide analogues, vitamins, and metal chelating agents) and polysaccharides chiefly β-glucans and glycoproteins. Due to the occurrence of biologically active substances, mushrooms can serve as hepatoprotective, immune-potentiating, anti-cancer, anti-viral, and hypocholesterolemic agents. They have great potential to prevent cardiovascular diseases due to their low fat and high fiber contents, as well as being foremost sources of natural antioxidants useful in reducing oxidative damages. However, mushrooms remained underutilized, despite their wide nutritional and bioactive potential. Novel green techniques are being explored for the extraction of bioactive components from edible mushrooms. The current review is intended to deliberate the nutraceutical potential of mushrooms, therapeutic properties, bioactive compounds, health benefits, and processing aspects of edible mushrooms for maintenance, and promotion of a healthy lifestyle.

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Section: Mushroom (Common Name) Bioactive Compounds Health Benefits Referencesmentioning

confidence: 99%

Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects

Kumar

Mehra

Guiné

et al. 2021

Foods

125

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show abstract

“…As a result, many research efforts have focused on low molecular weight compounds, such as cordycepin [ 14 ]. Of the mushroom-derived therapeutics, polysaccharopeptides obtained from Agaricus campestris , Pleurotus ostreatus and Coriolus versicolor [ 15 , 16 ], as well as Hericium erinaceus [ 17 ] are commercially the best established. While Coriolus versicolor is widely used to degrade recalcitrant organic pollutants such as pentachlorophenol (PCP) [ 18 ], H. erinaceus , has been used in traditional medical practices in China and Japan as to treat various human diseases.…”

Section: Introductionmentioning

confidence: 99%

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

et al. 2016

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BackgroundThere has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have long been used in traditional medicine for thousands of years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial and hepatoprotective agent also capable to stimulate host immune responses.ResultsHere we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat. Expression of Lipoxin A4 (LXA4) was measured in different brain regions after oral administration of a biomass Hericium preparation, given for 3 month. LXA4 up-regulation was associated with an increased content of redox sensitive proteins involved in cellular stress response, such as Hsp72, Heme oxygenase −1 and Thioredoxin. In the brain of rats receiving Hericium, maximum induction of LXA4 was observed in cortex, and hippocampus followed by substantia Nigra, striatum and cerebellum. Increasing evidence supports the notion that oxidative stress-driven neuroinflammation is a fundamental cause in neurodegenerative diseases. As prominent intracellular redox system involved in neuroprotection, the vitagene system is emerging as a neurohormetic potential target for novel cytoprotective interventions. Vitagenes encode for cytoprotective heat shock proteins 70, heme oxygenase-1, thioredoxin and Lipoxin A4. Emerging interest is now focussing on molecules capable of activating the vitagene system as novel therapeutic target to minimize deleterious consequences associated with free radical-induced cell damage, such as in neurodegeneration. LXA4 is an emerging endogenous eicosanoid able to promote resolution of inflammation, acting as an endogenous “braking signal” in the inflammatory process. In addition, Hsp system is emerging as key pathway for modulation to prevent neuronal dysfunction, caused by protein misfolding.ConclusionsConceivably, activation of LXA4 signaling and modulation of stress responsive vitagene proteins could serve as a potential therapeutic target for AD-related inflammation and neurodegenerative damage.

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“…Studies in rodents and humans suggest that polysaccharides derived from mushrooms can stimulate the immune system to attack malignant cells 78,79 and several of these compounds are now used in East countries in association to radio and chemotherapy 80 . In addition to the previous bioactive compounds, antiinflammatory peptides of different molecular weights have been isolated from mushrooms 81 . Cordymin, a low molecular weight peptide (10,906Da), has been purified from the medicinal mushroom Cordyceps sinensis 82 and from Cordyceps militaris 83 .…”

Section: Extracts and Bioactive Compounds Isolated From Coriolus Versmentioning

confidence: 99%

Neuroinflammation and Mitochondrial Dysfunction in the Pathogenesis of Alzheimer?s Disease: Modulation by Coriolus Versicolor (Yun-Zhi) Nutritional Mushroom

Calabrese¹

2017

J Neurol Neuromedicine

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Buried treasure: Unlocking the secrets of medicinal mushrooms

Cited by 6 publications

References 22 publications

Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects

Edible Mushrooms: A Comprehensive Review on Bioactive Compounds with Health Benefits and Processing Aspects

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

Neuroinflammation and Mitochondrial Dysfunction in the Pathogenesis of Alzheimer?s Disease: Modulation by Coriolus Versicolor (Yun-Zhi) Nutritional Mushroom

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